Speyer, historically known in English as Spires, is a city in Rhineland-Palatinate in Germany with approximately 50,000 inhabitants. Locateā¦Speyer, historically known in English as Spires, is a city in Rhineland-Palatinate in Germany with approximately 50,000 inhabitants. Located on the left bank of the river Rhine, Speyer lies 25 km south of Ludwigshafen and Mannheim, and 21 km south-west of Heidelberg. Founded by the Romans, it is one of Germany's oldest cities. Speyer Cathedral, a number of other churches, and the Altpörtel dominate the Speyer landscape. In the cathedral, beneath the high altar, are the tombs of eight Holy Roman Emperors and German kings.