WEBGuangzhou is the capital and largest city of Guangdong province in southern China. Located on the Pearl River about 120 km (75 mi) north-northwest of Hong Kong and 145 km (90 mi) north of Macau, Guangzhou has a history of over 2,200 years and was a major terminus of the Silk Road.. The port of Guangzhou serves as transportation hub and Guangzhou is one of China's three largest cities.