WEBLouisiana entrance sign off Interstate 20 in Madison Parish east of Tallulah. Louisiana [pronunciation 1] (French: Louisiane ⓘ; Spanish: Luisiana; Louisiana Creole: Lwizyàn) is a state in the Deep South and South Central regions of the United States.It borders Texas to the west, Arkansas to the north, and Mississippi to the east. Of the 50 U.S. states, it …