Aprotinin - Wikipedia
WebAprotinin is a competitive inhibitor of several serine proteases, specifically trypsin, chymotrypsin and plasmin at a concentration of about 125,000 IU/ml, and kallikrein at 300,000 IU/ml. [5] Its action on kallikrein leads to the inhibition of the formation of factor XIIa.
Aprotinin: Uses, Interactions, Mechanism of Action | DrugBank …
WebFeb 12, 2009 · DB06692. Background. Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). Since it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery.
Aprotinin: Indications, Side Effects, Warnings - Drugs.com
WebOct 19, 2023 · If you are allergic to aprotinin; any part of aprotinin; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have been given a drug that has aprotinin in it in the past 12 months. This is not a list of all drugs or health problems that interact with aprotinin.
Aprotinin - PubChem
WebAprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). Since it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery.
Aprotinin - an overview | ScienceDirect Topics
WebAprotinin, also known as bovine pancreatic trypsin inhibitor or BPTI (Trasylol, Bayer), is a drug used to reduce bleeding during cardiopulmonary bypass (CPB). Aprotinin slows down fibrinolysis, the process that leads to the breakdown of blood clots. Use of aprotinin is associated with AKI and this drug was withdrawn from the market.
Use and safety of aprotinin in routine clinical practice - PMC
WebJun 29, 2022 · Aprotinin is indicated for prophylactic use to reduce blood loss and blood product transfusions in adult patients who are at high risk of major blood loss undergoing isolated coronary artery bypass graft surgery (iCABG), 1, 2 that is CABG not combined with other cardiovascular surgery. Aprotinin has a broad action on proteolytic enzymes, such ...
Aprotinin Inhibits Thrombin Generation by Inhibition of the …
WebAug 31, 2021 · As aprotinin is a broad-spectrum serine protease inhibitor, other targets that may explain the mode of action of aprotinin as a hemostatic drug have been proposed. It has even been questioned whether the antifibrinolytic effect is a main contributor to the prohemostatic effect of aprotinin.
Renal effects of the serine protease inhibitor aprotinin in healthy ...
WebMar 23, 2021 · It is an unselective inhibitor of trypsin-like serine proteases such as trypsin, plasmin, plasma and tissue kallikreins, coagulation factor XII, and others [ 1 ]. Aprotinin was used as an ...
Aprotinin: a pharmacologic overview - PubMed
WebAprotinin is a polypeptide with serine protease inhibitory activity of key enzymes associated with inflammatory, fibrinolytic, and hemostatic pathways.
Aprotinin—Drug against Respiratory Diseases - PMC
WebJul 6, 2023 · Abstract. Aprotinin (APR) was discovered in 1930. APR is an effective pan-protease inhibitor, a typical “magic shotgun”. Until 2007, APR was widely used as an antithrombotic and anti-inflammatory drug in cardiac and noncardiac surgeries for reduction of bleeding and thus limiting the need for blood transfusion.
Skip to content