Caspase - Wikipedia
WebThe integral role caspases play in cell death and disease has led to research on using caspases as a drug target. For example, inflammatory caspase-1 has been implicated in causing autoimmune diseases; drugs blocking the activation of Caspase-1 have been used to improve the health of patients.
Caspase Functions in Cell Death and Disease - PMC - National …
WebCaspases are a family of genes important for maintaining homeostasis through regulating cell death and inflammation. Here we will attempt to summarize what we currently know about how caspases normally work, and what happens when members of this diverse gene family fail to work correctly.
Caspases and their substrates | Cell Death & Differentiation - Nature
WebMay 12, 2017 · Human caspases are a family of 12 fate-determining cysteine proteases that are best known for driving cell death, either apoptosis or pyroptosis.
Caspases in cell death, inflammation and disease - PMC
WebJun 6, 2019 · Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years.
Making the head: Caspases in life and death - PMC
WebJan 13, 2023 · This review aims to provide a comprehensive overview of recent knowledge concerning apoptosis-related molecules involved in the development of structures of head with a particular focus on caspases, cysteine proteases having a key position in …
A Review on Caspases: Key Regulators of Biological Activities and ...
WebCaspases have been broadly classified by their known roles in apoptosis (caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9 in mammals) and in inflammation (caspase-1, caspase-4, caspase-5, and caspase-12 in humans, and caspase-1, caspase-11, and caspase-12 in mice).
Old, new and emerging functions of caspases | Cell Death ... - Nature
WebDec 19, 2014 · Caspases are proteases with a well-defined role in apoptosis. However, increasing evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and caspase-11 have roles in...
A guide to cell death pathways | Nature Reviews Molecular Cell …
WebDec 18, 2023 · Caspases are classified based on the prodomain length (short or long) and sequence features (CARD or DED) as well as the functions (initiator caspase or downstream caspase). Caspase-8 is an ...
Caspases in Cell Death, Inflammation, and Disease - PubMed
WebJun 18, 2019 · Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in …
Human Caspases: Activation, Specificity, and Regulation*
WebCaspases are intracellular proteases that propagate programmed cell death, proliferation, and inflammation. Activation of caspases occurs by a conserved mechanism subject to strict cellular regulation.
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