Kinase - Wikipedia
WebIn biochemistry, a kinase ( / ˈkaɪneɪs, ˈkɪneɪs, - eɪz /) [2] is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates. This process is known as phosphorylation, where the high-energy ATP molecule donates a phosphate group to the substrate molecule.
Kinase | Definition, Biology, & Function | Britannica
Webkinase, an enzyme that adds phosphate groups (PO 4 3−) to other molecules. A large number of kinases exist—the human genome contains at least 500 kinase-encoding genes. Included among these enzymes’ targets for phosphate group addition (phosphorylation) are proteins, lipids, and nucleic acids.
Protein kinase - Wikipedia
WebA protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.
Protein Kinases: Function, Substrates, and Implication in Diseases
WebMar 24, 2022 · Protein kinases are important enzymes, involved in the regulation of various cellular processes. Phosphorylation and dephosphorylation provide a rapid and dynamic regulatory mechanism that controls the biological functions of most proteins and act as a molecular switch for diverse regulatory events in signaling pathways that drive cell …
An Introduction to Kinases - The Daily Scientist
WebDec 1, 2023 · Kinases are a group of enzymes that transfer phosphate groups from high-energy, donor molecules to specific target molecules, modulating their function. These enzymes play an important role in numerous biological processes, including cell cycle regulation, metabolic activity and signal transduction. Kinases come in a variety of forms …
Kinase drug discovery 20 years after imatinib: progress and future ...
WebMay 17, 2021 · Nature Reviews Drug Discovery - Twenty years have passed since the first small-molecule protein kinase inhibitor, imatinib, gained FDA approval. Here, Cohen et al. review advances in improving...
Protein Kinases: Structure, Function, and Regulation - iBiology
WebSusan Taylor gives an overview of protein kinase structure and function using cyclic AMP dependent kinase (PKA) as a prototype for this enzyme superfamily.
Catalytic Mechanisms and Regulation of Protein Kinases - PMC
WebThis protein kinase chapter is written from an enzymology perspective and will cover the kinetic and chemical mechanisms of kinases and how an understanding of these features has been used to explore the structure, function, and regulation of these important catalysts.
Function, Structure and Topology of Protein Kinases
WebMay 6, 2020 · Abstract. Protein kinases represent one of the most successful target classes for the development of new medicines. Because of their key roles in cellular signalling, kinases are stringently regulated by a large diversity of mechanisms such as post-translational modifications, interacting domains and proteins and cellular localization.
Ten things you should know about protein kinases: IUPHAR …
WebMar 24, 2015 · Protein and lipid kinases represent an important target class for treating human disorders. This review focus on ‘the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a perspective on kinase drug discovery.
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