Laminin - Wikipedia
WEBLaminins are a family of glycoproteins of the extracellular matrix of all animals. They are major constituents of the basement membrane, namely the basal lamina (the protein network foundation for most cells and organs). Laminins are vital to biological activity, influencing cell differentiation, migration, and adhesion. [1] [2]
Laminin - an overview | ScienceDirect Topics
WEBLaminins are high–molecular weight, heterotrimeric proteins that are found in the basement membrane, specifically the basal laminae. Laminins contain an α-chain, a β-chain, and a γ-chain. There are five genetic variants of the α-chain, four of …
Structural biology of laminins - PubMed
WEBSep 13, 2019 · Abstract. Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide chains.
Structural biology of laminins - PMC - National Center for ...
WEBSep 9, 2019 · Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide chains.
The laminin family - PMC - National Center for Biotechnology …
WEBJan 1, 2013 · Laminins are glycoproteins with both common and specific functions. One common and most important function of laminins is to interact with receptors anchored in the plasma membrane of cells adjacent to basement membranes. In doing so laminins regulate multiple cellular activities and signaling pathways.
13.5: Laminins - Biology LibreTexts
WEBDec 30, 2022 · Laminins are a family of secreted glycoproteins that are found in many ECM formations, and like fibronectin, bind to cells via integrin receptors. The laminin protein is composed of three subunits (α, β, γ) arranged in a cruciform shape. There are multiple isoforms of each subunit yielding the variety (15) of laminin proteins catalogued …
The laminin–keratin link shields the nucleus from mechanical ...
WEBSep 14, 2023 · In epithelial tissues, laminin is a very abundant extracellular matrix component and a key supporting element. Here we show that laminin hinders the mechanoresponses of breast epithelial cells...
Structural biology of laminins | Essays in Biochemistry - Portland …
WEBMay 15, 2019 · Laminins are large cell-adhesive glycoproteins that are required for the formation and function of basement membranes in all animals. Structural studies by electron microscopy in the early 1980s revealed a cross-shaped molecule, which subsequently was shown to consist of three distinct polypeptide chains.
Laminins in metabolic tissues - PubMed
WEBLaminins are extracellular matrix proteins that reside in the basement membrane and provide structural support in addition to promoting cellular adhesion and migration. Through interactions with cell surface receptors, laminins stimulate intracellular signaling cascades which direct specific survival and differentiation outcomes.
Laminin - PMC - National Center for Biotechnology Information
WEBMar 3, 2004 · Laminin-1 is emerging as the key molecule in early embryonic basement membrane assembly. Here we review recent insights into its functions gained from the synergistic application of genetic and structural methods. Keywords: extracellular matrix; embryo development; mutagenesis; structure determination.
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