Morpholine - Wikipedia
WEBMorpholine is an organic chemical compound having the chemical formula O(C H 2 CH 2) 2 NH. This heterocycle features both amine and ether functional groups. Because of the amine, morpholine is a base; its conjugate acid is called morpholinium. For example, treating morpholine with hydrochloric acid makes the salt morpholinium chloride.
Morpholine | C4H9NO | CID 8083 - PubChem
WEBJan 13, 2016 · Morpholine is an organic heteromonocyclic compound whose six-membered ring contains four carbon atoms and one nitrogen atom and one oxygen atom that lies opposite to each other; the parent compound of the morpholine family. It has a role as a NMR chemical shift reference compound.
Morpholine As a Scaffold in Medicinal Chemistry: An Update on …
WEBFeb 4, 2020 · Morpholine is a frequently used heterocycle in medicinal chemistry and a privileged structural component of bioactive molecules. This is mainly due to its contribution to a plethora of biological activities as well as to an improved pharmacokinetic profile of such bioactive molecules.
Morpholine - an overview | ScienceDirect Topics
WEBMorpholine shows nucleophilic character typical of secondary amines, and substituted tetrahydro-1,4-oxazines can also be reacted with various carbon electrophiles. For example, the pharmaceutically important, cycloalkane-fused tetrahydrooxazines have been N-alkylated using propyl iodide <1985EJM247> , ethyl bromide <1978CB1164> , as well as ...
Recent progress in the synthesis of morpholines | Chemistry of ...
WEBMay 30, 2019 · Explore all metrics. The morpholine (1,4-oxazinane) motif attracted significant attention due to its widespread availability in natural products and biologically relevant compounds. This review describes recent advances in the synthesis of morpholines and their carbonyl-containing analogs from 1,2-amino alcohols, aziridines, …
Morpholine | chemical compound | Britannica
WEBheterocyclic compounds. The parent tetrahydro-1,4-oxazine, commonly called morpholine, is produced on a large scale for use as a solvent, corrosion inhibitor, and fungicide. The morpholine ring is also present in the sedative-hypnotic drug trimetozine and in some fungicides such as tridemorph and fenpropimorph.
Morpholine as a privileged structure: A review on the medicinal ...
WEBSep 12, 2019 · Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules - Kourounakis - 2020 - Medicinal Research Reviews - Wiley Online Library.
Morpholine - an overview | ScienceDirect Topics
WEBIntroduction. Morpholine (1,4-tetrahydro-oxazine) is a simple heterocyclic compound that has great industrial importance and a wide range of applications. This chemical compound and its derivatives have been used as rubber additives, corrosion inhibitors, solvents, optical brighteners, antioxidants and in the manufacture of a range of drugs and ...
Morpholine - NIST Chemistry WebBook
WEBIUPAC Standard InChIKey: YNAVUWVOSKDBBP-UHFFFAOYSA-N Copy CAS Registry Number: 110-91-8 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. Other names: p-Isoxazine, tetrahydro-; BASF 238; Diethylene Imidoxide; Diethylene oximide; …
Morpholine - an overview | ScienceDirect Topics
WEBMorpholine and piperazine ring are essential motifs in diverse marked drugs and natural products. (R,R)-Reboxetine 147 is a well-known antidepressant drug that acts as a selective noradrenaline reuptake inhibitor (NaRI) [122].
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