Mucin - Wikipedia
WebClinical significance. Increased mucin production occurs in many adenocarcinomas, including cancers of the pancreas, lung, breast, ovary, colon and other tissues. Mucins are also overexpressed in lung diseases such as asthma, bronchitis, chronic obstructive pulmonary disease (COPD) or cystic fibrosis. [24]
Mucin - an overview | ScienceDirect Topics
WebMucins are: (1) lubricants easing the movement of the lids over the surface of the eye; (2) a physical barrier; (3) a trap for microbes; and (4) a matrix where tear constituents among which enzymes, antimicrobial peptides, and other signal molecules fulfill …
The Role and Function of Mucins and Its Relationship to …
WebMay 6, 2022 · Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production.
Mucus and Mucins: The Underappreciated Host Defence System
WebJun 14, 2022 · In this review, we highlight the dynamic function of the mucins and mucus during infection, how this mucosal barrier is regulated, and how pathogens have evolved mechanisms to evade this defence system. Keywords: mucins, mucus, mucosal epithelial cells, pathogen, microbes, barrier integrity, infection, host defence.
Immunological aspects of intestinal mucus and mucins - Nature
WebAug 8, 2016 · 521 Citations. 40 Altmetric. Metrics. Key Points. Mucins are highly O -glycosylated molecules that have gel-like properties. The mucin family consists of transmembrane mucins and gel-forming...
Mucins in cancer: function, prognosis and therapy - Nature
WebNature Reviews Cancer - The mucin family of transmembrane and secreted glycoproteins form a barrier that protects the epithelium. Mucins affect epithelial polarity, inflammation, and cell...
Mucus: Current Biology - Cell Press
WebAug 9, 2021 · Summary. Mucus is a slimy hydrogel that lines the mucosal surfaces in our body, including the intestines, stomach, eyes, lungs and urogenital tract. This glycoprotein-rich network is truly the jack of all trades.
Mucins: a biologically relevant glycan barrier in mucosal …
WebPMID: 24821013. DOI: 10.1016/j.bbagen.2014.05.003. Abstract. Background: The mucins found as components of mucus gel layers at mucosal surfaces throughout the body play roles in protection as part of the defensive barrier on an organ and tissue specific basis.
Role of mucins in lung homeostasis: regulated expression and ...
WebJun 6, 2018 · Abstract. In humans and mice, the first line of innate defense against inhaled pathogens and particles in the respiratory tract is airway mucus. The primary solid components of the mucus layer are the mucins MUC5AC and MUC5B, polymeric glycoproteins whose changes in abundance and structure …
Mucins in the mucosal barrier to infection | Mucosal Immunology
WebMar 5, 2008 · Mucins—an Integral Part of the Mucosal Barrier. Mucosal epithelial tissues have evolved multiple mechanisms of defense in response to their vulnerability to microbial attack due to their...
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