Perlecan - Wikipedia
WEBPerlecan is a large multidomain (five domains, labeled I-V) proteoglycan that binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules. Perlecan is synthesized by both vascular endothelial and smooth muscle cells and deposited in the extracellular matrix of parahoxozoans.
Perlecan: a review of its role in neurologic and musculoskeletal ...
WEBMay 30, 2023 · This is a narrative review article examining perlecan’s role in diseases of neural and musculoskeletal pathology and its potential as a therapeutic index. Analysis was conducted by utilizing the key phrases “perlecan” AND “brain,” “perlecan” AND “cartilage” and “Schwartz-Jampel Syndrome” in the PubMed database.
Perlecan, a heparan sulfate proteoglycan, regulates systemic
WEBMay 17, 2018 · Perlecan (HSPG2), a heparan sulfate proteoglycan, is a component of basement membranes and participates in a variety of biological activities. Here, we show physiological roles of perlecan in...
A current view of perlecan in physiology and pathology: A mosaic …
WEBPerlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a wide array of tissues where it regulates diverse cellular processes including bone formation, inflammation, cardiac development, and angiogenesis.
Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing ...
WEBApr 1, 2022 · Abstract. This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone marrow stroma and in …
Perlecan, a modular instructive proteoglycan with diverse …
WEBNov 1, 2020 · Perlecan is a heparan sulphate proteoglycan that transiently displays native CS sulphation motifs 4-C-3 and 7-D-4 during tissue morphogenesis these are expressed by progenitor cell populations during tissue development.
Perlecan - an overview | ScienceDirect Topics
WEBPerlecan expression is detected as early as the blastocyst stage, increases in the peri-implantation period, and in tissues for vasculogenesis, including heart, pericardium, and major blood vessels. Perlecan is also expressed in developing cartilage, especially in the hypertrophic zone.
Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing ...
WEBApr 1, 2022 · This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, lymphoreticular, bone and bone …
Perlecan, a modular instructive proteoglycan with diverse functional ...
WEBPerlecan is a heparan sulphate proteoglycan that transiently displays native CS sulphation motifs 4-C-3 and 7-D-4 during tissue morphogenesis these are expressed by progenitor cell populations during tissue development.
Perlecan - an overview | ScienceDirect Topics
WEBPerlecan is a secreted heparan sulfate proteoglycan that is a potential linker of laminin and collagen IV networks (Fig. 2 C). Perlecan is a large (> 200 nm), evolutionarily old (> 550 million years) ECM protein ( Farach-Carson, Warren, Harrington, & Carson, 2014 ).
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