XIAP - Wikipedia
WebX-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.
XIAP Gene - GeneCards | XIAP Protein | XIAP Antibody
WebApr 3, 2024 · XIAP (X-Linked Inhibitor Of Apoptosis) is a Protein Coding gene. Diseases associated with XIAP include Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome 2. Among its related pathways are SMAC (DIABLO) binds to IAPs and TNF signaling.
Evolution of Our Understanding of XIAP Deficiency - PMC
WebJun 17, 2021 · XIAP plays a key function in various immune pathways. (A) XIAP is required for pattern recognition receptors (PPR) mediated innate immune responses. (i) XIAP is essential for the NOD1/2 induced activation of the NF-κB and MAPK pathways and secretion of pro-inflammatory cytokines and chemokines .
XIAP deficiency syndrome in humans - PubMed
WebXIAP deficiency can be considered as one of the genetic causes for inherited IBD. XIAP is an anti-apoptotic molecule, but it is also involved in many other pathways. Recent findings demonstrate the role of XIAP in innate immunity and in …
XIAP’s Profile in Human Cancer - PMC - National Center for ...
WebOct 29, 2020 · XIAP, the X-linked inhibitor of apoptosis protein, regulates cell death signaling pathways through binding and inhibiting caspases. Mounting experimental research associated with XIAP has shown it to be a master regulator of cell death not only in apoptosis, but also in autophagy and necroptosis.
XIAP X-linked inhibitor of apoptosis [ (human)] - National Center …
WebFeb 12, 2024 · XIAP gene RNAi inhibited proliferation of ovarian carcinoma cells and caused cells to be sensitive to cisplatin through the reduction of its mRNA and protein. XIAP is an ovarian cancer-related gene and potential target for therapeutic anti-cancer drugs.
XIAP gene: MedlinePlus Genetics
WebThe XIAP gene provides instructions for making a protein that is found in many types of cells, including immune cells. It helps protect these cells from self-destructing (undergoing apoptosis) by blocking (inhibiting) the action of certain enzymes called caspases, which are necessary for apoptosis.
XIAP, the guardian angel | Nature Reviews Molecular Cell Biology
WebJul 1, 2001 · Abstract. Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged...
XIAP as a ubiquitin ligase in cellular signaling | Cell Death ...
WebJul 10, 2009 · Abstract. The ability of the vertebrate X-linked inhibitor of apoptosis (XIAP) protein to directly suppress apoptotic cell death pathways has been the subject of much research....
Regulation of Cell Death and Immunity by XIAP - PubMed
WebAug 3, 2020 · X-chromosome-linked inhibitor of apoptosis protein (XIAP) controls cell survival in several regulated cell death pathways and coordinates a range of inflammatory signaling events. Initially identified as a caspase-binding protein, it was considered to be primarily involved in blocking apoptosis from ….
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