Acetylation - Wikipedia
WebIn chemistry, acetylation is an organic esterification reaction with acetic acid. It introduces an acetyl group into a chemical compound. Such compounds are termed acetate esters or simply acetates. Deacetylation is the opposite reaction, the removal of an acetyl group from a chemical compound.
Protein acylation: mechanisms, biological functions and …
WebDec 29, 2022 · Protein kinases bind ATP and use it to phosphorylate other proteins. Acetylation is known to regulate kinase activity through impairing or enhancing ATP binding.
What is Acetylation? - News-Medical.net
WebFeb 23, 2023 · Acetylation is a chemical reaction that is called ethanoylation in the IUPAC nomenclature. It describes a reaction that introduces an acetyl functional group into a chemical compound. The opposite ...
Protein acylation: mechanisms, biological functions and …
WebDec 29, 2022 · Biological function of protein acetylation. All lysine acetyltransferases (KATs) require acetyl-CoA as donor for acetylation reactions. Reciprocally, protein lysine acetylation represents an important mechanism to regulate overall energy metabolisms through either metabolic enzymes or transcription factors.
Functions and mechanisms of non-histone protein acetylation
WebNov 22, 2018 · Acetylation affects protein functions through diverse mechanisms, including by regulating protein stability, enzymatic activity, subcellular localization and crosstalk with other post ...
Protein acetylation in metabolism — metabolites and cofactors
WebOct 27, 2015 · Acetylation is a key post-translational modification that integrates metabolic flux and physiological processes within cells, including circadian rhythm, cell cycle and energy production. Lysine...
Protein acetylation - Wikipedia
WebAcetylation is an important modification of proteins in cell biology; and proteomics studies have identified thousands of acetylated mammalian proteins. [1] [2] [3] Acetylation occurs as a co-translational and post-translational modification of proteins, for example, histones, p53, and tubulins.
The world of protein acetylation - PubMed
WebIn recent years, our understanding of protein acetylation has increased significantly by global proteomics analyses and in depth functional studies. This review gives a general overview of protein acetylation and the respective acetyltransferases, and focuses on the regulation of metabolic processes and physiological consequences that come ...
Acetylation - an overview | ScienceDirect Topics
WebAcetylation is a very common metabolic reaction which occurs with amino, hydroxyl or sulfhydryl groups. The acetyl group is transferred from acetyl-coenzyme A and the reaction is catalysed by acetyltransferases.
Mechanisms, Detection, and Relevance of Protein Acetylation in ...
WebApr 9, 2019 · Protein acetylation typically occurs on reactive amino acids containing primary amino groups, hydroxyl groups, or sulfhydryl groups (23,– 31). Although acetylation of side chains of cysteines, serines, and threonines has been reported, we will focus this review on N-acetylation of primary amino groups (e.g., of lysine).
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