Adipogenesis - Wikipedia
WEBAdipogenesis is the formation of adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as lipoblasts or preadipocytes which lose the potential to differentiate to other types of cells such as ...
Adipogenesis and metabolic health | Nature Reviews Molecular …
WEBJan 4, 2019 · Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health...
Adipogenesis as a Potential Anti-Obesity Target: A Review of ...
WEBJan 8, 2021 · Adipogenesis is a process of proliferation and differentiation of adipocyte precursor cells in mature adipocytes. As a key process in determining the number of adipocytes, it is a possible therapeutic approach for obesity.
Adipogenesis: A Complex Interplay of Multiple Molecular
WEBJun 16, 2020 · Adipogenesis consists of two phases, namely commitment and terminal differentiation. This review discusses the role of signalling pathways, epigenetic modifiers, and transcription factors in preadipocyte commitment and differentiation into mature adipocytes, as well as limitations in our understanding of these processes.
Adipogenesis: A Complex Interplay of Multiple Molecular …
WEBJun 16, 2020 · Adipogenesis is a complex multi-step process that involves the differentiation of MSCs into mature, lipid containing adipocytes [8,33,34]. Two phases have been recognized: commitment and terminal differentiation.
Adipogenesis: A Necessary but Harmful Strategy - PMC
WEBJul 26, 2019 · Adipogenesis, in physiological conditions, is characterized by a pro-inflammatory state, angiogenesis, and the healthy release of adipokines, but it can become dangerous to health if it results in a hypoxic state, causing uncontrolled inflammation and the synthesis and release of harmful free fatty acids.
Adipogenesis and metabolic health - PubMed
WEBAdipogenesis and metabolic health. Nat Rev Mol Cell Biol. 2019 Apr;20 (4):242-258. doi: 10.1038/s41580-018-0093-z. Authors. Alexandra L Ghaben 1 , Philipp E Scherer 2. Affiliations. 1 Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
A spatiotemporal proteomic map of human adipogenesis - Nature
WEBApr 2, 2024 · White adipocytes function as major energy reservoirs in humans by storing substantial amounts of triglycerides, and their dysfunction is associated with metabolic disorders; however, the mechanisms...
Cellular and molecular brakes on adipogenesis - Nature
WEBJan 13, 2022 · a, Adipogenesis, a process that has been shown to be a prerequisite for healthy adipose tissue expansion, is defined as the emergence of newly formed adipocytes from...
Adipogenesis - an overview | ScienceDirect Topics
WEBAdipogenesis is the process by which fat-laden cells, that is, adipocytes, develop and accumulate as adipose tissue at various sites in the body, both as subcutaneous fat and as depots. The major roles of adipocytes are to store energy as fat during periods when energy intake exceeds expenditure and to mobilize this stored fuel when energy ...
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