Aptamer - Wikipedia
WEBAptamers are short sequences of artificial DNA, RNA, XNA, or peptide that bind a specific target molecule, or family of target molecules. They exhibit a range of affinities ( K D in the pM to μM range), [1] [2] with variable levels of off-target binding [3] and are sometimes classified as chemical antibodies.
Aptamers: A Review of Their Chemical Properties and …
WEBNov 21, 2019 · Abstract. Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies.
Recent Advances in Aptamer Discovery and Applications - PMC
WEBMar 7, 2019 · Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be developed with high affinity and specificity to interact with any desired targets. They have been widely used in facilitating discoveries in basic research, ensuring food safety and monitoring the environment.
Aptamers as targeted therapeutics: current potential and ... - Nature
WEBNov 3, 2016 · Nucleic acid aptamers, often termed chemical antibodies, are short, single-stranded DNA or RNA molecules (20–100 nucleotides in length) with defined structures that can specifically bind to a...
Aptamer - an overview | ScienceDirect Topics
WEBAptamers are small, functional nucleic acids that bind a variety of targets, often with high specificity and affinity. Genomic aptamers constitute the ligand-binding domains of riboswitches, whereas synthetic aptamers find applications as diagnostic and therapeutic tools, and as ligand-binding domains of regulatory RNAs in synthetic biology.
Analysis of aptamer discovery and technology - Nature
WEBOct 4, 2017 · Aptamers are nucleic acid molecules that mimic antibodies by folding into complex 3D shapes that bind to specific targets. Although some aptamers exist naturally as the ligand-binding elements...
Current Perspectives on Aptamers as Diagnostic Tools and …
WEBJul 9, 2020 · 1. Introduction. Aptamers are a class of small single-stranded DNA or RNA oligonucleotides, with a three-dimensional structure enabling the target binding and specificity. The synthesis of aptamers is based on an in vitro evolution procedure, known as ‘Systematic Evolution of Ligands by EXponential Enrichment’ (SELEX) [ 1, 2 ].
Aptamers as therapeutics | Nature Reviews Drug Discovery
WEBAug 1, 2010 · Aptamers are single-stranded oligonucleotides that fold into defined architectures and bind to targets such as proteins. In binding proteins they often inhibit protein–protein interactions and...
Recent Progress in Aptamer Discoveries and Modifications for ...
WEBNucleic acid aptamers are chemically synthesized analogues (chemical antibodies) of conventional antibodies that exhibit a great many advantages in therapeutic applications. Aptamer technology demonstrates great potential in producing candidate bio-active agents and plays a dramatically important role in the subsequent therapeutic field.
What is an Aptamer? – Aptamers and SELEX - Base Pair Bio
WEBAptamers are short, single-stranded DNA or RNA (ssDNA or ssRNA) molecules that can selectively bind to a specific target, including proteins, peptides, carbohydrates, small molecules, toxins, and even live cells. Aptamers assume a variety of shapes due to their tendency to form helices and single-stranded loops.
Aptamers 101: aptamer discovery and in vitro applications in
WEBMay 2, 2023 · Aptamers are single-stranded nucleic acids that bind and recognize targets much like antibodies. Recently, aptamers have garnered increased interest due to their unique properties, including inexpensive production, simple chemical modification, and …
What Is An Aptamer? - Aptamer Group
WEBAptamers are synthetic affinity molecules that can specifically bind to both large and small molecules. The ability of aptamers to act as antibody mimetics means that aptamers can be substituted for antibodies in a wide variety of applications, such as therapeutic targeting, biosensors, and affinity chromatography.
Aptamers: A Review of Their Chemical Properties and …
WEBNov 21, 2019 · Aptamers are short, single-stranded oligonucleotides that bind to specific target molecules. The shape-forming feature of single-stranded oligonucleotides provides high affinity and excellent specificity toward targets. Hence, aptamers can be used as analogs of antibodies.
Aptamers: an emerging navigation tool of therapeutic agents …
WEBAptamers are short, single-stranded DNA or RNA molecules that are able to recognize target molecules through their three-dimensional (3D) conformation with high binding affinity. 16,17 Since Ellington et al. and Tuerk et al. reported for the first time an in vitro method that could screen RNA species specifically recognizing their ligands, aptam...
Aptamers and Their Biological Applications - PMC - National …
WEBJan 9, 2012 · 1. Introduction. Aptamers are oligonucleotides, such as ribonucleic acid (RNA) and single-strand deoxyribonucleic acid (ssDNA) or peptide molecules that can bind to their targets with high affinity and specificity due to …
What Are Aptamers? vs. Antibodies, Definition, Applications
WEBWhat is an aptamer? Aptamers (synthetic antibodies) are (stable) single-stranded DNA, RNA, or peptide molecules capable of binding to its target antigen with high affinity and specificity. Aptamers (synthetic antibodies) have been developed against a wide variety of targets ranging from small organics to large proteins. Benefits:
In vitro selection of aptamers and their applications - Nature
WEBJul 20, 2023 · Aptamers offer specificity and affinity normally expected of antibodies but in small, chemically synthesized molecules free from cell culture-derived contaminants. Additionally, aptamers can be...
Development of a Specific Aptamer‐Modified Nano‐System to …
WEB2 days ago · The EA1 ssDNA aptamer, which binds robustly to ESCC cells with high specificity and affinity, is identified using cell-based systematic evolution of ligands by exponential enrichment (cell-SELEX). An EA1-modified nano-system is developed using a natural egg yolk lipid nanovector (EA1-EYLNs-PTX/siEFNA1) that concurrently loads …
Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for …
WEBApr 29, 2024 · The aptamer also overcomes the difficulty of targeting c-Myc due to its nuclear localization. We put forward that aptamers are powerful tools to solve ligand deficiency. No attempt should be left aside to overcome the challenge of degradation of the undruggable c-Myc. The ProMyc selectively targeting the c-Myc for proteasome …
Maptamer
WEBWelcome to Maptamer.org. Mapping Aptamer Research. At Maptamer.org, we are dedicated to creating a comprehensive and permanent database of aptamers for use in biomedical and bioengineering projects.
Aptamer decorated PDA@magnetic silica microparticles for …
WEBApr 23, 2024 · Aptamer#1 specificity showed a maximum of 15% binding to control mixture bacteria. Aptamer#3 showed a maximum of 20% binding with slightly less specificity. According to these results, it was concluded that Aptamer#1 could be implemented in the magnetic purification system with a better performance.
Zentek subsidiary achieves positive results against H5N1 using
WEBMore specifically, the aptamer is believed to bind to and neutralize multiple subtypes of the HA surface protein (e.g., H1, H2, H5, etc.), preventing the virus from entering healthy cells and ...
Aptamers in the Therapeutics and Diagnostics Pipelines - PMC
WEBJul 1, 2018 · Aptamers are short single-stranded DNA or RNA oligonucleotides that can selectively bind to small molecular ligands or protein targets with high affinity and specificity, by acquiring unique three-dimensional structures.
Zentek subsidiary achieves positive results against H5N1 using ...
WEB19 hours ago · More specifically, the aptamer is believed to bind to and neutralize multiple subtypes of the HA surface protein (e.g., H1, H2, H5, etc.), preventing the virus from entering healthy cells and ...
AptaNet as a deep learning approach for aptamer–protein
WEBMar 16, 2021 · Aptamers are short oligonucleotides (DNA/RNA) or peptide molecules that can selectively bind to their specific targets with high specificity and affinity. As a powerful new class of amino acid...
Zentek and Triera Biosciences Ltd. Achieve Positive Results Against ...
WEB20 hours ago · This aptamer solution could radically reduce the impact from a pandemic outbreak in a timely and efficient manner. Based on the SARS-CoV-2 experience, I believe that Triera can find a solution to ...
Antitumor Effect of Anti-c-Myc Aptamer-Based PROTAC for
WEBApr 29, 2024 · The multifunctional aptamer-based Proteolysis Targeting Chimeras (PROTAC) for proteolysis of the c-Myc (ProMyc) is developed using the aptamer MA9C1 as the ligand. ProMyc not only significantly degrades c-Myc by the ubiquitin-proteasome system, but also reduces the Max protein, synergistically inhibiting c-Myc transcriptional …
Aptamers, the Nucleic Acid Antibodies, in Cancer Therapy
WEBApr 17, 2020 · Aptamers are single-stranded nucleic acids (either DNA or RNA) that can recognize targets through three-dimensional complementarity (rather than base pairing) and bind to targets with high specificity and affinity; hence, they have been described as nucleic acid antibodies [ 3 ].
A comparative analysis of cell surface targeting aptamers
WEBNov 1, 2021 · Aptamers represent a potentially important class of ligands for the development of diagnostics and therapeutics. However, it is often difficult to compare the function and specificity of many of...
Zentek Ltd.: Zentek and Triera Biosciences Ltd. Achieve Positive ...
WEB20 hours ago · This aptamer solution could radically reduce the impact from a pandemic outbreak in a timely and efficient manner. Based on the SARS-CoV-2 experience, I believe that Triera can find a solution to ...
Machine learning guided aptamer refinement and discovery
WEBApr 22, 2021 · Aptamers are single-stranded nucleic acid ligands that bind to target molecules with high affinity and specificity. They are typically discovered by searching large libraries for sequences with...
Development of Aptamer-DNAzyme based metal-nucleic acid
WEB5 days ago · The development of metal-nucleic acid nanocomposites for therapeutic is limited by poor stability and synthesis efficiency. Here, the authors develop a multi-fragmented aptamer DNAzyme metal ...
Zentek and Triera Biosciences Ltd. Achieve Positive ... - Morningstar
WEB1 day ago · This aptamer solution could radically reduce the impact from a pandemic outbreak in a timely and efficient manner. Based on the SARS-CoV-2 experience, I believe that Triera can find a solution to ...
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