Aromatase - Wikipedia
WEBAromatase ( EC 1.14.14.14 ), also called estrogen synthetase or estrogen synthase, is an enzyme responsible for a key step in the biosynthesis of estrogens. It is CYP19A1, a member of the cytochrome P450 superfamily, which are monooxygenases that catalyze many reactions involved in steroidogenesis.
Aromatase Inhibitors: Uses, Dosage, Side Effects, Interactions
WEBJan 26, 2023 · Indications. Aromatase inhibitors are approved to reduce the risk of recurrence in postmenopausal women with estrogen receptor-positive breast cancer. They can also be used to treat advanced breast cancer, including stage 4 breast cancer, in which the malignancy has spread ( metastasized) to other parts of the body.
Breast Cancer Prevention: Aromatase Inhibitors
WEBWhat are aromatase inhibitors? Aromatase inhibitors (AIs) lower estrogen levels by stopping an enzyme in fat tissue (called aromatase) from changing other hormones into estrogen. (Estrogen can fuel the growth of breast cancer cells.) These drugs don’t stop the ovaries from making estrogen.
Aromatase Inhibitors: Benefits, Side Effects, and More - Breastcancer.org
WEBAromatase inhibitors work by blocking the enzyme aromatase, which turns the hormone androgen into small amounts of estrogen in the body. Doctors use aromatase inhibitors to treat hormone receptor-positive breast cancer that relies on estrogen to grow.
Aromatase - an overview | ScienceDirect Topics
WEBAromatase is a cytochrome P450 enzyme that catalyzes a critical step in the conversion of androgens (C19 steroids) to estrogens (C18 steroids). Mutations in the aromatase gene (CYP19A1) can result in a lack of aromatase activity and, as a consequence, impairment in estrogen biosynthesis.
Aromatase: Contributions to Physiology and Disease in Women …
WEBJun 1, 2016 · Abstract. Aromatase (estrogen synthetase; EC 1.14.14.1) catalyzes the demethylation of androgens' carbon 19, producing phenolic 18-carbon estrogens. Aromatase is most widely known for its roles in reproduction and reproductive system diseases, and as a target for inhibitor therapy in estrogen-sensitive diseases including …
Aromatase - an overview | ScienceDirect Topics
WEBAromatase, also known as estrogen synthase, is a member of cytochrome P450 superfamily. This enzyme is responsible for estrogen biosynthesis. Aromatase mainly converts androgens into estrogens by aromatization. AIs can block the production of aromatase and impede estrogen synthesis.
Tissue Physiology and Pathology of Aromatase - PMC
WEBOestradiol, the most active member of the group of hormones known as oestrogens, is crucial for the normal function of a broad range of cells and organs. All oestrogens are synthesised from androgen precursors by a unique enzyme called aromatase, more specifically classified as cytochrome P450 aromatase (CYP19a1).
Aromatase in the Human Brain - PMC - National Center for …
WEBHere, we summarize the current knowledge about aromatase expression in the human brain, abundant in the thalamus, amygdala, hypothalamus, cortex, and hippocampus and discuss its role in the regulation of sensory integration, body homeostasis, social behavior, cognition, language, and integrative functions.
Aromatase expression and regulation in breast and endometrial …
WEBEstrogen plays a critical role in tumor formation and growth, and provides a therapeutic target for the prevention and treatment of breast and endometrial cancers. Aromatase is the rate-limiting enzyme in estrogen biosynthesis, with expression driven by multiple tissue-specific, untranslated and alternative promoters.
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