An overview of the c-MET signaling pathway - PMC
WEBAbstract. c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.
Structural basis of the activation of c-MET receptor - Nature
WEBJul 1, 2021 · C-MET can be activated by either hepatocyte growth factor (HGF), or its natural isoform NK1. Here, we report the cryo-EM structures of c-MET/HGF and c-MET/NK1 complexes in the active...
HGF/c-MET pathway in cancer: from molecular characterization to ...
WEBJun 18, 2021 · This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers.
Function of the c-Met receptor tyrosine kinase in carcinogenesis …
WEBFeb 19, 2018 · c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. The binding of HGF to c-Met initiates a series of intracellular signals that mediate embryogenesis and wound healing in normal …
c-MET as a potential therapeutic target and biomarker in cancer
WEBThis review provides an overview of the evidence to support c-MET or the HGF/c-MET signaling pathway as relevant targets for personalized cancer treatment based on high frequencies of c-MET and/or HGF overexpression, activation, amplification in non-small cell lung carcinoma (NSCLC), gastric, ovarian, pancreatic, thyroid, breast, head and neck ...
The Emerging Role of c-Met in Carcinogenesis and Clinical …
WEBJan 13, 2022 · c-MET is a receptor tyrosine kinase receptor (RTK) for the hepatocyte growth factor (HGF). The binding of HGF to c-MET regulates several cellular functions: differentiation, proliferation, epithelial cell motility, angiogenesis, and epithelial-mesenchymal transition (EMT). Moreover, it is known to be involved in carcinogenesis.
The c-MET oncoprotein: Function, mechanisms of degradation …
WEBOct 1, 2020 · Oncogenic c-Met signaling induces cell scattering, cell migration/invasion, cell survival, cell proliferation, angiogenesis and resistance to targeted therapies, leading to tumor growth and metastasis. c-Met signaling targets diverse molecules including: Rho, MAPK, Egr1 (cell scattering), FAK, cdc42/Rac1, MMPs, integrins (cell migration ...
HGF/c-MET pathway in cancer: from molecular characterization to ...
WEBThis review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor (HGF) /mesenchymal-epithelial transition factor (c-MET)) signaling pathway in cancers. First, we generalize the compelling influence of HGF/c-MET pathway on …
c-Met enforces proinflammatory and migratory features of …
WEBJun 28, 2021 · 1 Altmetric. Metrics. The receptor tyrosine kinase c-Met is essential for embryonic development and tissue regeneration, as it promotes cell survival, proliferation, migration, and angiogenesis ...
An overview of the c-MET signaling pathway - PubMed
WEBAbstract. c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor, activates a wide range of different cellular signaling pathways, including those involved in proliferation, motility, migration and invasion.
Skip to content