Cathepsin - Wikipedia
WEBClinical significance. Cathepsin A. Cathepsin B. Cathepsin D. Cathepsin K. Cathepsin V. Inhibitors. Cathepsin zymography. History. References. External links. Cathepsins ( Ancient Greek kata- "down" and hepsein "boil"; abbreviated CTS) are proteases ( enzymes that degrade proteins) found in all animals as well as other organisms.
Cathepsins: Proteases that are vital for survival but can also be fatal
WEBJun 6, 2018 · Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the nucleophiles, which are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide synthesis, among a litany of other functions. But inflammatory state radically affects their normal roles.
The Ins and Outs of Cathepsins - National Center for …
WEBJul 13, 2020 · Abstract. Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune responses among a host of other functions.
Cysteine cathepsins: From structure, function and regulation to …
WEBOct 12, 2011 · Current advances in the field of cysteine cathepsins and their regulation. Cysteine cathepsin activity as a delicate balance of various factors. Structure of cysteine cathepsins and their mechanism of interaction with inhibitors. Inhibition of cysteine cathepsins by protein and small-molecule inhibitors. The increased expression of cys...
Cysteine cathepsins: From structure, function and regulation …
WEBJan 1, 2012 · Current advances in the field of cysteine cathepsins and their regulation. Cysteine cathepsin activity as a delicate balance of various factors. Structure of cysteine cathepsins and their mechanism of interaction with inhibitors. Inhibition of cysteine cathepsins by protein and small-molecule inhibitors. The increased expression of …
The Ins and Outs of Cathepsins: Physiological Function and Role in ...
WEBJul 13, 2020 · In this review, we summarize the available evidence regarding the role of cathepsins in health and disease, discuss their potential as biomarkers of disease progression, and shed light on the potential of extracellular cathepsin inhibitors as safe therapeutic tools.
The Ins and Outs of Cathepsins - MDPI
WEBJul 13, 2020 · Cathepsins are the most abundant lysosomal proteases that are mainly found in acidic endo/lysosomal compartments where they play a vital role in intracellular protein degradation, energy metabolism, and immune …
Cathepsin - an overview | ScienceDirect Topics
WEBCathepsin - an overview | ScienceDirect Topics. Cathepsins. Heidrun Kirschke, in xPharm: The Comprehensive Pharmacology Reference, 2007. Introduction. The term cathepsin was originally used to name a variety of intracellular peptidases discovered during …
Cathepsin K: its skeletal actions and role as a therapeutic ... - Nature
WEBJun 14, 2011 · Cathepsin K, a cysteine protease that is highly expressed in osteoclasts, degrades proteins present in the organic matrix of bone, and, therefore, has a fundamental role in bone resorption.
Cysteine protease cathepsins in cardiovascular disease: from …
WEBApr 20, 2018 · Cathepsin actions in cardiovascular diseases include the regulation of cell–cell interactions, intracellular signalling, protein expression, angiogenesis, cholesterol metabolism, cell migration,...
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