Chondrocyte - Wikipedia
WEBChondrocytes (/ ˈ k ɒ n d r ə s aɪ t,-d r oʊ-/, from Greek χόνδρος, chondros = cartilage + κύτος, kytos = cell) are the only cells found in healthy cartilage. They produce and maintain the cartilaginous matrix, which consists mainly of collagen and proteoglycans .
Histology, Chondrocytes - StatPearls - NCBI Bookshelf
WEBApr 17, 2023 · Chondrocytes maintain the extracellular matrix (ECM) and produce the cartilage matrix. Surrounded by collagenous fibers, chondrocytes release substances to make cartilage strong yet flexible. In general, chondrocytes are found within intervertebral discs and in any form of articular cartilage (AC).
Chondrocytes: anatomy and function | Kenhub
WEBMar 19, 2024 · Anatomy, histology and definition of cartilage. Chondrocytes produce collagen and the extracellular matrix. They are found in the avascular tissue known as cartilage . The extracellular matrix that is produced by the chondrocytes is important in the maintenance of cartilaginous tissue.
Role of Chondrocytes in Cartilage Formation, Progression of ...
WEBChondrocytes in the AC proliferate and secrete extracellular matrix to maintain and sustain the cartilage. The cells themselves are separated from each other by cartilage matrix . They respond to outside stimuli and tissue damage, and are also responsible for degenerative conditions, such as osteoarthritis (OA).
A high-resolution route map reveals distinct stages of chondrocyte ...
WEBApr 27, 2022 · Early-stage chondrocytes exhibited a glycolytic phenotype with increased expression of genes involved in metabolism and antioxidation, whereas late-stage chondrocytes exhibited ultrastructural...
Chondrocyte - an overview | ScienceDirect Topics
WEBChondrocytes restart proliferation in a relatively uniform manner within the cartilaginous template. As the cartilage enlarges, chondrocytes stop proliferating in the center, drastically change their cell morphology, and become special …
Molecular Mechanisms of Chondrocyte Proliferation and …
WEBMay 28, 2021 · Chondrocytes originate from bone marrow mesenchymal stem cells (BMSCs). First, aggregated BMSCs are capable of differentiating into chondroprogenitor cells. Then these chondroprogenitor cells become chondrocytes that undergo a series of differentiation processes and develop into hypertrophic chondrocytes (Figure 1). Finally, …
Mechanisms of Disease: role of chondrocytes in the ... - Nature
WEB186 Citations. Metrics. Abstract. The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage degradation. However, cartilage cells have a pivotal role during...
Mechanosignalling in cartilage: an emerging target for the ... - Nature
WEBDec 21, 2021 · Chondrocytes sense their physical environment via an array of mechanosensitive receptors and channels that activate a complex network of downstream signalling pathways to regulate several cell...
Chondrogenesis, chondrocyte differentiation, and articular cartilage ...
WEBFollowing chondrogenesis, the chondrocytes remain as resting cells to form the articular cartilage or undergo proliferation, terminal differentiation to chondrocyte hypertrophy, and apoptosis in a process termed endochondral ossification, whereby the hypertrophic cartilage is replaced by bone.
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