Conessine - Wikipedia
WebConessine is a steroidal alkaloid found in a number of plant species from the family Apocynaceae, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H 3 subtype (with an affinity of pK i = 8.27; K i = ~5 nM).
Conessine | C24H40N2 | CID 441082 - PubChem
WebConessine is a steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae. It has a role as an antibacterial agent, an antimalarial, a H3 …
Benefits Of Conessine - MyBioHack
WebMay 15, 2020 · 1. May Improve Cognition. Conessine also easily crosses the Blood-Brain Barrier (BBB). Conessine is a H3 antagonist and increases Histamine in the brain, which can increase cognitive function. Conessine also increases the neurotransmitter Acetylcholine (ACh) in the brain by reducing the activity of …
Conessine | C24H40N2 | ChemSpider
WebConessine. Molecular Formula C 24 H 40 N 2; Average mass 356.588 Da; Monoisotopic mass 356.319153 Da; ChemSpider ID 389885
Conessine as a novel inhibitor of multidrug efflux pump ... - PubMed
WebAug 14, 2017 · Results: Conessine significantly reduced MICs of all antibiotics by at least 8-fold in MexAB-OprM overexpressed strain. The levels were comparable to those obtained in wild-type strain for cefotaxime, levofloxacin, and tetracycline.
Metabolic Diversity and Therapeutic Potential of
WebSep 18, 2020 · Conessine is Major Compound Responsible for Antimicrobial Activity Siriyong et al. concluded that conessine in H. pubescens is responsible for antibacterial activity and can be useful as a combinatory therapy to restore antibiotic susceptibility in the extensively drug-resistant A. baumannii [ 137 ].
Conessine as a novel inhibitor of multidrug efflux pump systems …
WebAug 14, 2017 · Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa - PMC. Journal List. BMC Complement Altern Med. v.17; 2017. PMC5557310. As a library, NLM provides access to scientific literature.
Conessine - Wikiwand
WebConessine is a steroidal alkaloid found in a number of plant species from the family Apocynaceae, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H 3 subtype (with an affinity of pK i = 8.27; K i = ~5 nM).
Conessine - an overview | ScienceDirect Topics
WebThe bark juice of this plant, under the name Kalindu, is reputed in Sri Lankan native medicine as a remedy for dysentery and fevers ( 9). In addition to the isolation of conessine(190) from the bark of this plant, during their early investigations Bhavanandan and Wannigama obtained evidence for the occurrence of N -demethylated conessines ( 110 ).
Conessine treatment reduces dexamethasone-induced muscle
WebKeywords: Conessine; FoxO3a; MuRF1; Muscle atrophy; atrogin-1. Conessine, a steroidal alkaloid, is a potent histamine H3 antagonist with anti-malarial activity. We recently reported that conessine treatment interferes with H₂O₂-induced cell death by regulating autophagy.
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