Downregulation and upregulation - Wikipedia
WEBIn biochemistry, in the biological context of organisms' regulation of gene expression and production of gene products, downregulation is the process by which a cell decreases the production and quantities of its cellular components, such as RNA and proteins, in response to an external stimulus.
Downregulation Definition & Meaning | Merriam-Webster Medical
WEBThe meaning of DOWNREGULATION is the process of reducing or suppressing a response to a stimulus; specifically : reduction in a cellular response to a molecule (as insulin) due to a decrease in the number of receptors on the cell surface.
Receptor down Regulation - an overview | ScienceDirect Topics
WEBReceptor down Regulation. Receptor downregulation is mediated by specific loss of cell surface receptors, which occurs via an energy-dependent internalization of the ligand-receptor complex, in which the principal internalization pathway involves processing of the receptor-ligand complex into lysosomes and subsequent degradation …
GoodTherapy | The Biology of Calm: How Downregulation Pro...
WEBOct 27, 2016 · Self-regulation of the autonomic nervous system (ANS) can essentially be broken down into two opposing functions: it goes up or it goes down! In a car, we can press the gas pedal to access...
Emotion Regulation | Psychology Today
WEBWhile there are many ways to influence one’s emotional state for the better, emotion regulation often involves what experts call “down-regulation,” or reducing the intensity of emotions. A...
Short- and long-term effects of emotion up- and down-regulation …
WEBNov 9, 2023 · Down-regulation of negative emotions is often argued to be the most adaptive form of emotion regulation, whereas up-regulation of negative emotions—for example, by cognitive strategies such as worrying or rumination—is a key feature of several mental disorders ( Aldao, Nolen-Hoeksema, & Schweizer, 2010 ).
down Regulation - an overview | ScienceDirect Topics
WEBDownregulation, indicated by reduced B max calculated from saturation binding isotherms, generally occurs over a period of hours after prolonged agonist activation of receptors or activation of downstream signaling pathways; this process can be distinguished from changes in agonist binding affinity (K d) that often are associated with …
Receptor downregulation and desensitization enhance the …
WEBNov 9, 2007 · Receptor downregulation and desensitization increase the filter bandwidth thereby enabling the receptor systems to decode inputs in a wider frequency range. Further, system-theoretic analysis reveals that the receptor systems are analogous to classical mechanical over-damped systems.
Optimal Down Regulation of mRNA Translation | Scientific …
WEBJan 25, 2017 · Down-regulation of translation is important in cell biology, medicine, and biotechnology. Indeed, diverse viruses down regulate host translation by cleaving proteins such as eIF4G 8 in order to...
Downregulation and Upregulation - an overview - ScienceDirect
WEBBoth 1,25 (OH) 2 D and the VDR are required for down-regulation and up-regulation of 1α (OH)ase and 24 (OH)ase gene expression in vivo [1,44,45]. However, elimination of the hypocalcemia alone, using the rescue diet, normalized 24 (OH)ase levels in the 1α (OH)ase –/– mice and both 1α (OH)ase and 24 (OH)ase levels in VDR –/– mice [15].
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