Endotoxin | Gram-negative, Lipopolysaccharide, Immune Response
WebEndotoxin, toxic substance bound to the bacterial cell wall and released when the bacterium ruptures or disintegrates. Endotoxins consist of lipopolysaccharide and lipoprotein complexes. The protein component determines its foreign (antigenic) nature; the polysaccharide component determines the.
Endotoxin - an overview | ScienceDirect Topics
WebEndotoxins (lipopolysaccharides from the membrane of gram negative bacteria) make up the majority of pyrogens which must be removed from pharmaceutical products, biologicals for injection and some media for tissue cultures. Endotoxins in solution range from molecular weights of 10,000 to 1,000,000.
Bacterial endotoxins: biological properties and mechanisms of …
WebEndotoxins (lipopolysaccharides, LPS) are agents of pathogenicity of Gram-negative bacteria, implicated in the development of Gram-negative shock. Endotoxin reacts with lipopolysaccharide-sensitive cells producing endogenous mediators such as tumour necrosis factor alpha (TNFα).
Lipopolysaccharide - Wikipedia
WebEndotoxins are in large part responsible for the dramatic clinical manifestations of infections with pathogenic Gram-negative bacteria, such as Neisseria meningitidis, the pathogens that causes meningococcal disease, including meningococcemia, Waterhouse–Friderichsen syndrome, and meningitis.
Bacterial endotoxins and exotoxins in intensive care medicine
WebMar 12, 2022 · This article discusses bacterial toxins and describes the common disease states they cause. Toxins are generally categorised into endotoxins and exotoxins. Endotoxins are lipopolysaccharides (LPS) and cause Gram-negative sepsis. Exotoxins are peptides that are mostly secreted by Gram-positive bacteria.
Endotoxin in Human Disease - CHEST
WebWe begin with a brief overview of the biochemistry and pharmacology of endotoxin, and then discuss evidence that it plays a role in several human disease states: sepsis, liver failure, burns, bowel diseases, and pancreatitis.
Endotoxin - an overview | ScienceDirect Topics
WebEndotoxin, one of the components of the outer wall of gram-negative bacteria, is released by the microbiota in the gut and is directly introduced into the liver via portal blood. Endotoxin is considered to play an important role in …
The biology of endotoxin - PubMed
WebEndotoxins. Endotoxin (lipopolysaccharide, LPS) is the major component of the outer leaflet of Gram-negative bacteria and has profound immunostimulatory and inflammatory capacity. The septic shock syndrome caused by endotoxin still has an unacceptably high mortality rate and, owing to increasing numbers of resi …
Endotoxin: Structure Source and Effects | SpringerLink
WebJan 13, 2023 · Endotoxins are insoluble parts of the bacterial cells able to evoke a typical clinical picture characterizing bacterial infection. Usually, Gram-negative bacteria are a major part of the gut microbiota and are a source of endotoxins, particularly lipopolysaccharide (LPS).
The Importance of Food for Endotoxemia and an Inflammatory …
WebSep 3, 2021 · Endotoxins circulate in the blood at low concentrations in all healthy individuals. Elevated levels of circulatory endotoxins may cause inflammation with the development of chronic disease, either affecting metabolism, neurological disease, or resistance to viral and bacterial infections.
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