Epitope - Wikipedia
WebAn epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that binds to the epitope is called a paratope. Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as ...
What is an Epitope? - News-Medical.net
WebMay 10, 2021 · An epitope is the part of an antigen that the host’s immune system recognizes, eliciting the immune response to an invading pathogen. It specifically binds to the...
Epitope | Description & Function | Britannica
WebEpitope, portion of a foreign protein, or antigen, that is capable of stimulating an immune response. An epitope is the part of the antigen that binds to a specific antigen receptor on the surface of a B cell. Binding between the receptor and epitope occurs only if …
Epitopes: Types, Function, Epitope Spreading • Microbe Online
WebJun 1, 2021 · Written by Acharya Tankeshwar in Immunology Last Updated June 1, 2021. Epitopes, also known as antigenic determinants, are the immunologically active discrete sites on the antigen molecule that physically bind to antibodies, B-cell receptors, or T-cell receptors. When an antibody binds to an antigen, it isn’t binding to the entire antigen but ...
Epitope - an overview | ScienceDirect Topics
WebThe epitopes can be categorized into two types: linear and conformational. Linear epitopes are usually composed of sequential amino acids that participate in antibody binding and their interaction is based on the primary structure of the epitope.
Epitope - an overview | ScienceDirect Topics
WebEpitopes or antigenic determinants are regions of proteins that can trigger a cellular immune response mediated by T or B cells. T cell epitopes are usually protein antigen-derived peptides presented by MHC molecules on antigen-presenting cells and recognized by T-cell receptors.
Fundamentals and Methods for T- and B-Cell Epitope Prediction
WebDec 28, 2017 · There are many distinct peptides within antigens and T-cell prediction methods aim to identify those that are immunogenic. T-cell epitope immunogenicity is contingent on three basic steps: (i) antigen processing, (ii) peptide binding to MHC molecules, and (iii) recognition by a cognate TCR.
An Introduction to Epitope Mapping - PubMed
WebSpecialized methods for mapping of the two different classes of epitopes, using high-throughput or high-resolution methods, have been developed. While different in their detail, all of the experimental methods rely on assessing the binding of the antibody to the antigen or a set of antigen mimics.
Epitope - an overview | ScienceDirect Topics
WebPeptide epitopes recognized by CTLs may be useful immunogens for HIV and M. tuberculosis or immunotherapy for chronic diseases such as hepatitis B. CTL peptide epitopes generally are poor immunogens.
An Introduction to B-Cell Epitope Mapping and In Silico Epitope ...
WebDec 29, 2016 · In this paper, we have comprehensively reviewed state-of-the-art experimental methods for B-cell epitope identification, existing databases for epitopes, and novel in silico resources and prediction tools available online. We have also elaborated new trends in the antibody-based epitope prediction.
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