Ganglioside - Wikipedia
WEBThe name ganglioside was first applied by the German scientist Ernst Klenk in 1942 to lipids newly isolated from ganglion cells of the brain. More than 60 gangliosides are known, which differ from each other mainly in the position and number of NANA residues.
Structures, biosynthesis, and functions of gangliosides—An overview
WEBAbstract. Gangliosides are sialic acid-containing glycosphingolipids that are most abundant in the nervous system. Heterogeneity and diversity of the structures in their carbohydrate chains are characteristic hallmarks of these lipids; so far, 188 gangliosides with different carbohydrate structures have been identified in vertebrates.
Gangliosides in the Brain: Physiology, Pathophysiology and …
WEBOct 6, 2020 · Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane microdomains (“lipid rafts”) and play important roles in the modulation of membrane proteins and ion channels, in cell signaling and in the communication among …
Physiology of gangliosides and the role of antiganglioside antibodies ...
WEBMar 9, 2020 · The present review will discuss the multiple roles of gangliosides and their key components, sialic acids, in shielding human and microbial cells from immune attack, determining species ...
Gangliosides in nervous system development, regeneration, and ...
WEBApr 25, 2022 · Gangliosides are widely expressed in mammalian tissues but are particularly abundant in the nervous system, where they were originally isolated and characterized (Klenk, 1942). They occur primarily on the surface of neuronal cells and are enriched at the synaptic sites.
Gangliosides: Structures, Biosynthesis, Analysis, and Roles in
WEBJul 4, 2017 · Abstract. Gangliosides are acidic glycosphingolipids containing one or more sialic acid residues. They are essential compounds at the outer leaflet of the plasma membrane, where they interact with phospholipids, cholesterol, and transmembrane proteins, forming lipid rafts. They are involved in cell adhesion, proliferation, and …
Gangliosides in the Brain: Physiology, Pathophysiology and
WEBOct 6, 2020 · Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane microdomains ("lipid rafts") and play important roles in the modulation of membrane proteins and ion channels, in cell signal ….
Gangliosides and Gangliosidoses: Principles of Molecular and …
WEBJun 19, 2013 · Ganglioside biosynthesis and its defects in genetically manipulated mice. Glycolipids are expressed in a cell-type- and stage-specific manner, gangliosides being the main glycolipids of neuronal surfaces. Their surface patterns are generated by coordinated processes, involving biosynthetic and catabolic steps and intracellular trafficking ...
Ganglioside - an overview | ScienceDirect Topics
WEBIn mammalian cells, gangliosides are involved in both types of interactions, functioning as receptors and modulators, mostly for proteins. In addition, gangliosides play a vital role in forming transient nanosized domains called lipid rafts, 24 which are important platforms for cell signaling and membrane trafficking.
Ganglioside - an overview | ScienceDirect Topics
WEBIt is well known that gangliosides, sialic acid-containing glycosphingolipids, play important roles in diverse biological processes associated with cell development, immune response, cancer metastasis, infection, and signal transduction.
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