Glycosylation - Wikipedia
WebGlycosylation is the reaction in which a carbohydrate (or 'glycan'), i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor) in order to form a glycoconjugate.
Glycosylation in health and disease | Nature Reviews Nephrology
WebMar 11, 2019 · Glycosylation refers to the addition of carbohydrate chains to proteins and lipids. In this Review, the authors discuss the broad role of glycans in immunity, cancer,...
Global view of human protein glycosylation pathways and functions - Nature
WebOct 21, 2020 · Protein glycosylation is a complex, multistep process that employs around 200 glycosyltransferase enzymes that determine which proteins are to become glycoproteins,...
Cellular Organization of Glycosylation - Essentials of Glycobiology ...
WebThis chapter provides an overview of glycosylation from the perspective of a single cell, taking into account the patterns of expression, topology, and other features of the biosynthetic and degradative enzymes that are common to most cell types. The focus is mostly on the organization of glycosylation in eukaryotic cells.
Protein glycosylation: Current Biology - Cell Press
WebApr 1, 2019 · What is protein glycosylation? Protein glycosylation is the covalent attachment of single sugars or glycans, i.e., multi-sugar polysaccharides or complex oligosaccharides, to select residues of target proteins.
An Overview of Glycosylation and its Impact on Cardiovascular …
WebNov 16, 2021 · Glycosylation is the most frequent post-translational modification in proteins because about half of the known proteins in eukaryote cells are glycosylated.
Introduction to Glycosylation: new methodologies and …
WebGlycosylation is the key reaction by which the complex carbohydrate structures (glycans) that are found in glycoproteins, glycolipids and other biologically important glycoconjugate structures, are assembled. One of the key considerations of glycosylation, and most difficult aspect to control, is the anomeric stereochemistry of the product.
WebMar 11, 2019 · In fact, changes in glycosylation can modulate inflammatory responses, enable viral immune escape, promote cancer cell metastasis or regulate apoptosis; the composition of the glycome also...
Glycosylation - an overview | ScienceDirect Topics
WebGlycosylation is a highly prevalent posttranslational modification to fungal cellulases that is required for optimal enzymatic function. We know that glycans on cellulases are crucial for maintaining thermal, proteolytic, and pH stability as well as playing crucial roles in processive cellulase catalytic activity on crystalline cellulose.
Understanding glycosylation: Regulation through the metabolic …
WebOct 1, 2023 · Glycosylation is a highly dynamic, multi-layered post-translational modification. •. Metabolic flux through precursor pathways is vital for sustained glycan synthesis. •. Inflammation induces profound glycosylation changes. •. Metabolic inhibition of glycan synthesis results in altered glycosylation signature. Abstract.
Skip to content