Kininogen - Wikipedia
WEBKininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, inflammatory regulation, and the regulation of the cardiovascular and renal systems.
Kininogen - an overview | ScienceDirect Topics
WEBKininogen (KNG) is the precursor protein of the kallikrein-kinin system (KKS). High molecular weight (HMW) and low molecular weight (LMW) KNGs are formed by alternative splicing of kng1 in mammals. HMW KNG interacts with plasma kallikrein to produce bradykinin (BK) and is involved in the contact activation of the blood coagulation process.
High-molecular-weight kininogen - Wikipedia
WEBHigh-molecular-weight kininogen (HMWK or HK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the kallikrein-kinin system. HMWK is inactive until it either adheres to binding proteins beneath an endothelium disrupted by injury, thereby initiating ...
Kininogen 1 - Wikipedia
WEBKininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that in humans is encoded by the KNG1 gene. Kininogen-1 is the precursor protein to high-molecular-weight kininogen (HMWK), low-molecular-weight kininogen (LMWK), and bradykinin.
High Molecular Weight Kininogen: A Review of the Structural …
WEBDec 13, 2021 · Abstract. Kininogens are multidomain glycoproteins found in the blood of most vertebrates. High molecular weight kininogen demonstrate both carrier and co-factor activity as part of the intrinsic pathway of coagulation, leading to thrombin generation. Kininogens are the source of the vasoactive nonapeptide bradykinin.
Human plasma kallikrein-kinin system: Physiological and biochemical ...
WEBThe plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high molecular weight kininogen (HK).
Kininogen - ScienceDirect
WEBJan 1, 2021 · Kininogen (KNG) is the precursor protein of the kallikrein-kinin system (KKS). High molecular-weight (HMW) and low molecular-weight (LMW) KNGs are formed by the alternative splicing of kng1 in mammals. HMW-KNG interacts with plasma kallikrein to produce bradykinin (BK) and is involved in the contact activation of …
Human Kininogen Gene Is Transactivated by the Farnesoid X …
WEBOpen Access DOI: https://doi.org/10.1074/jbc.M304568200. Human Kininogen Gene Is Transactivated by the Farnesoid X Receptor*. Human kininogen belongs to the plasma kallikreinkinin system. High molecular weight kininogen is the precursor for two-chain kinin-free kininogen and bradykinin.
Crosstalk between the renin–angiotensin, complement and ... - Nature
WEBNov 10, 2021 · This work shows that neutrophil-derived proteinase 3 cleaves high-molecular-weight kininogen, generating a vasoactive peptide, PR3-kinin, that binds to B1R, and this pathway circumvents kallikrein ...
The kallikrein–kinin pathway as a mechanism for auto-control ... - Nature
WEBMay 1, 2020 · Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides auto-regulatory inhibitory signaling in brown adipose tissue.
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