LPIN1 - Wikipedia
WEBFunction. Lipin-1 has phosphatidate phosphatase activity. [9] [10] [11] The nuclear localization of Lipin 1 is regulated by the mammalian Target Of Rapamycin protein kinase and links mTORC1 activity to the regulation of Sterol regulatory element-binding proteins ( SREBP )-dependent gene transcription. [12] [13] [14] Clinical significance.
Lipin proteins and metabolic homeostasis - PMC - National …
WEBLipin proteins and metabolic homeostasis. The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria ...
Lipin Definition & Meaning | Merriam-Webster Medical
WEBThe meaning of LIPIN is lipid; especially : a complex lipid (as a phosphatide or a cerebroside).
Lipin Family Proteins: Structure, Functions, and Related Diseases ...
WEBAug 3, 2021 · Lipins are Mg 2+ -dependent phosphohydrolases that catalyze the dephosphorylation of phosphatidic acid (PA) to diacylglycerol (DAG) and inorganic phosphate. These enzymes are currently receiving much attention because they belong to the class of endoplasmic reticulum (ER) proteins.
Role of lipins in cardiovascular diseases | Lipids in Health and ...
WEBNov 14, 2023 · Lipin 1, lipin 2, and lipin 3 are identified as the three members of the lipin protein family. All family members contain several conserved regions, i.e., an amino-terminal domain (N-LIP), a carboxy-terminal lipin domain (C-LIP), and a middle lipin domain (M-LIP) [ 9 , 10 ], and two key functional motifs within the C-LIP domain known …
Lipin family proteins--key regulators in lipid metabolism
WEBAbstract. Background: Proteins in the lipin family play a key role in lipid synthesis due to their phosphatidate phosphatase activity, and they also act as transcriptional coactivators to regulate the expression of genes involved in lipid metabolism. The lipin family includes three members, lipin1, lipin2, and lipin3, which exhibit tissue ...
Lipins: Multifunctional Lipid Metabolism Proteins - PMC
WEBAug 8, 2010 · Lipin proteins are present in organisms ranging from yeast to man and play a fundamental role in cellular metabolism. All lipin proteins appear to function as PAP enzymes that play a key role in glycerolipid biosynthesis. The mammalian lipins may also have roles in the regulation of gene expression through activity as transcriptional …
The Lipin Family: Mutations and Metabolism - PMC - National …
WEBLipin-1 and lipin-2 are required for normal lipid homeostasis, and have unique physiological roles. Future studies, for example using engineered mouse models, will be required to fully elucidate their specific roles in normal physiology and disease.
Lipins: Multifunctional Lipid Metabolism Proteins | Annual …
WEBThe lipin proteins are evolutionarily conserved proteins with roles in lipid metabolism and disease. There are three lipin protein family members in mammals and one or two orthologs in plants, invertebrates, and single-celled eukaryotes. Studies in yeast and mouse led to the identification of two distinct molecular functions of lipin proteins.
Lipin - The bridge between hepatic glycerolipid biosynthesis …
WEBThis review summarizes the current understanding of the role that hepatic lipin-1 plays in the synthesis, storage and compartmentalization of glycerolipids, and highlights the lipid metabolic consequences associated with dysregulated lipin expression.
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