Macrocycle - Wikipedia
WEBMacrocycles are often described as molecules and ions containing a ring of twelve or more atoms. Classical examples include the crown ethers, calixarenes, porphyrins, and cyclodextrins. Macrocycles describe a large, mature area of chemistry. [2] IUPAC definition for macrocycle in polymer chemistry.
Macrocyclic ligand - Wikipedia
WEBIn coordination chemistry, a macrocyclic ligand is a macrocyclic ring having at least nine atoms (including all hetero atoms) and three or more donor sites that serve as ligands. [1] . Crown ethers and porphyrins are prominent examples. Macrocyclic ligands often exhibit high affinity for metal ions, the macrocyclic effect . History [ edit]
The exploration of macrocycles for drug discovery - Nature
WEBMacrocyclic natural products have evolved to fulfil numerous biochemical functions, and their profound pharmacological properties have led to their development as drugs. A macrocycle provides...
Design, synthesis and applications of responsive macrocycles
WEBDec 17, 2020 · Inspired by the lock and key principle, the development of supramolecular macrocyclic chemistry has promoted the prosperous growth of host-guest chemistry. The updated induced-fit and...
Macrocycles: lessons from the distant past, recent developments, …
WEBMacrocycles, which are cyclic compounds comprising 12 atoms or more, are now recognized as molecules that “are up to the task” to interrogate extended protein interfaces.
Macrocyclic Compound - an overview | ScienceDirect Topics
WEBMacrocyclic compounds, a type of host compound with a large ring-shaped structure, were discovered and reported by American chemists in the 1960s.
Macrocyclic Chemistry - an overview | ScienceDirect Topics
WEBMacrocyclic compounds are capable of emulating enzymes. The macrocyclic host can selectively bind a guest molecule isolating it, and any subsequent chemical reactions, from the surrounding solvent or other medium.
Expansive discovery of chemically diverse structured macrocyclic …
WEB3 days ago · Small cyclic peptides, or macrocycles, are a common structural class for natural products because their constrained flexibility facilitates binding to other biological molecules. Salveson et al. used a deep neural network to generate energy surfaces and extract low-energy conformations for macrocycles built from a combination of 130 amino …
Macrocycles: lessons from the distant past, recent developments, …
WEBJan 1, 2015 · Macrocycles, which are cyclic compounds comprising 12 atoms or more, are now recognized as molecules that “are up to the task” to interrogate extended protein interfaces.
Macrocyclic Compounds: Emerging Opportunities for Current …
WEBThe macrocycles representing a unique chemical structure bridging conventional small molecules and large biomolecules, have attracted more and more attention in drug discovery over the past decade, and tremendous progress has been made toward the macrocyclization synthesis and structure diversification recently.
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