Neuroprotection - Wikipedia
WEBNeuroprotection refers to the relative preservation of neuronal structure and/or function. [1] . In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal loss over time, which can be expressed as a differential equation. [1] .
Neuroproteomics: understanding the molecular organization …
WEBIn combination with bioinformatics, neuroproteomics can address the organization of dynamic, functional protein networks and macromolecular structures that underlie physiological, anatomical and...
Neuroprotection in acute brain injury: an up-to-date review
WEBDec 1, 2015 · 104 Citations. 63 Altmetric. Metrics. Abstract. Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, …
Life | Special Issue : Advances in Neuroprotein Research ... - MDPI
WEBApr 19, 2024 · Neuroproteins, including key molecules such as Tau, α-synuclein and amyloid-β, play critical roles in both neural function and pathology. Dysregulation of these proteins is often a crucial factor in neurodegenerative conditions.
New technique identifies proteins in the living brain
WEBAug 11, 2021 · Protein targeting plays catch-up. While genetic targeting has completely transformed biology and neuroscience, protein targeting has woefully lagged behind. Researchers can amplify and sequence genes and RNA to identify their exact building blocks. Proteins, however, cannot be amplified and sequenced in the same manner.
Neurofilament Proteins as Biomarkers to Monitor Neurological …
WEBSep 27, 2021 · Neurofilament proteins (NfPs) are well suited as biomarkers in these contexts because they are major neuron-specific components that maintain structural integrity and are sensitive to neurodegeneration and neuronal injury across a wide range of neurologic diseases.
Hallmarks of neurodegenerative diseases: Cell
WEBFeb 16, 2023 · In this review, we argue that a set of hallmarks define NDDs, namely: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy metabolism, DNA and RNA defects, inflammation, and neuronal cell death ( Figure 1 ). Figure …
Neuropeptides in Alzheimer's Disease: An Update - PubMed
WEBNeuropeptides are small proteins broadly expressed throughout the central nervous system, which act as neurotransmitters, neuromodulators and neuroregulators. Growing evidence has demonstrated the involvement of many neuropeptides in both neurophysiological functions and neuropathological conditions …
Neuroproteins in Cancer: Assumed Bystanders Become Culprits
WEBWhile the usual explanation was that neuroproteins were actually not specific to the nervous system and were therefore also expressed in cancer cells, it now appears that the presence of neuroproteins in cancer is largely due to the infiltration of nerves in the tumor microenvironment.
Neuroprotein dynamics in the cerebrospinal fluid: intraindividual ...
WEBObjective: The measurement of neuromarker/neuroproteins in the cerebrospinal fluid (CSF) is gaining increased popularity. However, insufficient information is available on the rostrocaudal distribution of neuroproteins in the CSF to guarantee an appropriate interpretation of ventricular versus lumbar concentrations.
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