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OPGL - the link between T cell activation and bone loss
WEBMar 23, 2000 · Ligation of RANK by OPGL causes osteoclast maturation and promotes bone resorption. This interaction is regulated by a soluble decoy receptor, OPG, which ligates OPGL and prevents bone loss.
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The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature ...
WEBMay 5, 1999 · OPGL Stimulates a Rapid Onset of Hypercalcemia in Mice. Because OPGL stimulation of isolated OCs induced rearrangement of the cytoskeleton within 30 min, and increased bone resorption in vitro, we examined whether OPGL could rapidly stimulate bone resorption by activating preexisting OCs in vivo.
OPGL is a key regulator of osteoclastogenesis, lymphocyte
WEBJan 28, 1999 · The tumour-necrosis-factor-family molecule osteoprotegerin ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and...
Osteoprotegerin ligand: a regulator of immune responses and …
WEBThe TNF-family molecule osteoprotegerin ligand (OPGL, also known as TRANCE, RANKL and ODF) is a key regulator of bone remodeling and essential for the development and activation of osteoclasts. Intriguingly, OPGL also regulates T cell–dendritic cell communications, dendritic cell survival and lymph-node organogenesis.
OPGL is a key regulator of osteoclastogenesis and bone morphogenesis ...
WEBOct 16, 1999 · These data show that OPGL is required for lymph node organogenesis and T cell activation, and that OPGL is an essential regulator of osteoclast development. Here, the author discusses novel findings on the role of …
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