Sirolimus - Wikipedia
WebSirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor .
What is rapamycin? | New Scientist
WebBy Graham Lawton. Rapamycin. Shutterstock/Image Source Trading Ltd. If you like the idea of living as long as possible, rapamycin may be the drug for you. Originally developed as an...
Rapamycin: one drug, many effects - PMC - National Center for ...
WebMar 4, 2014 · Rapamycin, a specific inhibitor of mTOR, has been shown to be useful in the treatment of certain diseases. Here we discuss its mechanism of action and highlight recent findings regarding the effects and limitations of rapamycin monotherapy and the potential utility of combination therapy with rapamycin. Go to:
Rapamycin for longevity: opinion article - PMC - National Center …
WebOct 10, 2019 · At anti-aging doses, rapamycin “eliminates hyperimmunity rather than suppresses immunity” or, more figuratively, it “rejuvenates immunity” [ 2 ]. This enables rapamycin and everolimus, a rapamycin analog, to act as immunostimulators [ 4 – 6 ], improving immunity in cancer patients [ 7] and the elderly [ 8, 9 ].
Rapamycin: The next anti-aging drug? - Medical News Today
WebSep 7, 2022 · Image credit: miwa_in_oz/Getty Images. Rapamycin, also known as sirolimus, is an immunosuppressant drug that was approved by the Food and Drug Administration (FDA) in 1999. Researchers have known...
Rapamycin | Immunosuppressant, Antifungal, Anticancer
WebMar 17, 2024 · Rapamycin, drug characterized primarily by its ability to suppress the immune system, which led to its use in the prevention of transplant rejection. Rapamycin is produced by the soil bacterium Streptomyces hygroscopicus. The drug’s name comes from Rapa Nui, the indigenous name of Easter Island,
Targeting the biology of aging with mTOR inhibitors - Nature
WebMay 4, 2023 · 29 Citations. 223 Altmetric. Metrics. Abstract. Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic...
Rapamycin: Extending Health Span and Life Span - PMC
WebRapamycin treatment has increased life span by 25% to 60% in most species it has been tested on. 1 When rapamycin was given to 20-month (elderly) mice, females lived 14% longer and males lived 9% longer. 2 This is equal to an increase of approximately 7 years in the life span. These results suggest that rapamycin started late in life may also ...
How a drug for transplant patients became known for anti-aging …
WebMar 15, 2024 · Rapamycin, a drug for transplant patients, has extended the lives of animals but is unproven in people. By Daniel Gilbert. Updated March 15, 2024 at 12:00 p.m. EDT | Published March 15, 2024 at...
overview of rapamycin: from discovery to future perspectives …
WebMay 1, 2017 · Rapamycin is an immunosuppressive metabolite produced from several actinomycete species. Besides its immunosuppressive activity, rapamycin and its analogs have additional therapeutic potentials, including antifungal, antitumor, neuroprotective/neuroregenerative, and lifespan extension activities.
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