About Mutations in the RET Gene - Memorial Sloan Kettering Cancer Center
WEBJul 21, 2023 · Your RET gene normally helps prevent cancers. A mutation in this gene causes it to stop working like it should. It is important to understand that having a mutation in this gene does not mean you will definitely develop cancer. It means that you have an increased risk of developing certain types of cancers.
RET inhibitors: A treatment for any RET-altered cancer
WEBNovember 07, 2022. RET inhibitors: A treatment for any RET-altered cancer. BY Devon Carter. Cancer research is advancing rapidly, and patients are benefitting from new therapies faster than ever. One example is a type of targeted therapy known as a …
RET gene: MedlinePlus Genetics
WEBThe RET gene provides instructions for producing a protein that is involved in signaling within cells. Learn about this gene and related health conditions.
RET receptor signaling: Function in development, metabolic …
WEBMar 3, 2022 · The RET proto-oncogene encodes a receptor tyrosine kinase whose alterations are responsible for various human cancers and developmental disorders, including thyroid cancer, non-small cell lung cancer, multiple endocrine neoplasia type 2, and Hirschsprung’s disease. RET receptors are physiologically activated by glial cell line …
The importance of the RET gene in thyroid cancer and therapeutic ...
WEBFeb 18, 2021 · Introduction. Since the discovery of the RET gene in 1985, considerable progress has been made in the understanding of its physiology and role in diseases, particularly thyroid cancer. RET...
RET Gene - GeneCards | RET Protein | RET Antibody
WEBApr 3, 2024 · RET (Ret Proto-Oncogene) is a Protein Coding gene. Diseases associated with RET include Hirschsprung Disease 1 and Multiple Endocrine Neoplasia, Type Iia. Among its related pathways are Gene expression …
New Drug Gives Young Thyroid Cancer Patient a Second Chance at Life
WEBJan 9, 2021 · RET-inhibitors attack the RET protein in thyroid cancers and lung cancers with the RET gene mutation. In addition to pralsetinib, the Food and Drug Administration (FDA) approved selpercatinib (Retevmo), another RET inhibitor, on May 8, 2020.
WEBA positive test for the RET biomarker means that you are eligible for targeted therapy. Targeted therapy drugs keep cancer from growing and spreading with less harm to cells that aren’t cancer. The U.S. Food and Drug Administration has approved two drugs to …
Selpercatinib Approved for Thyroid and Lung Cancers - NCI
WEBJun 15, 2020 · RET is a type of protein called a kinase, which is involved in various cell processes. Selpercatinib “was designed to target RET while minimizing its activity against other kinases.
RET Inhibitors in Non-Small-Cell Lung Cancer - PMC
WEBSep 1, 2021 · Introduction. The RET (Rearranged during Transfection) gene encodes a single-pass transmembrane receptor tyrosine kinase (RTK) physiologically involved in renal morphogenesis, neural and neuroendocrine tissue development as well as spermatogonial stem cell maintenance.
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