Spermine - Wikipedia
WebSpermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid ornithine. It is an essential growth factor in some bacteria as well. It is found as a polycation at physiological pH.
Spermidine - Wikipedia
WebSpermidine is a polyamine compound ( C. 7H. 19N. 3) found in ribosomes and living tissues and having various metabolic functions within organisms. It was originally isolated from semen. [1] Function. Spermidine is an aliphatic polyamine. Spermidine synthase (SPDS) catalyzes its formation from putrescine.
The function of spermine - PubMed
WebThis review describes these alterations and focuses on the roles of spermine which may contribute to these phenotypes including reducing damage due to reactive oxygen species, protection from stress, permitting correct current flow through inwardly rectifying K(+) channels, controlling activity of brain glutamate receptors involved in learning ...
Spermine | C10H26N4 | CID 1103 - PubChem
WebModify: 2024-04-27. Description. Spermine is a polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism. It has a role as an antioxidant, an immunosuppressive agent and a fundamental metabolite.
Polyamines: Functions, Metabolism, and Role in Human Disease …
WebJun 9, 2021 · Putrescine, spermine, and spermidine are the important polyamines (PAs), found in all living organisms. PAs are formed by the decarboxylation of amino acids, and they facilitate cell growth and development via different cellular responses.
Spermine - an overview | ScienceDirect Topics
WebSpermine is an endogenous polyamine bearing multiple amino groups. It has been found to play important roles in cellular metabolism in all eukaryotic cells. It also can condense DNA in sperm due to its positive charge in the physiological condition.
The function of spermine - Pegg - 2014 - IUBMB
WebJan 6, 2014 · Spermine is the most strongly basic polyamine and the great majority of the cellular spermine is bound to acidic sites on macromolecules. Release of spermine from these sites is likely to induce the polyamine back-conversion/catabolic pathways that generate spermidine (Fig. 1 A).
The Potential Role of Spermine and Its Acetylated Derivative in …
WebJan 23, 2022 · Among all, spermine, which is considered one of the most important polyamines produced in mammalian cells were reported to be involved in playing important roles in cell physiology, for instance, ion channel regulation, bone development, inhibition of lipid formation and involvement in the maturation of gut and immune systems [ 7 ].
The natural polyamine spermine functions directly as a free ... - PNAS
WebSep 15, 1998 · The polyamine spermine, which is normally found in millimolar concentrations in the nucleus, is shown here to function directly as a free radical scavenger, and adducts formed as a result of this function are identified. These data suggest that spermine is a major natural intracellular compound capable of protecting DNA from free …
Spermine synthase and MYC cooperate to maintain colorectal
WebJun 26, 2020 · 50 Citations. 52 Altmetric. Metrics. This article has been updated. Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism...
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