Sulfatase - Wikipedia
WEBIn biochemistry, sulfatases EC 3.1.6.- are a class of enzymes of the esterase class that catalyze the hydrolysis of sulfate esters into an alcohol and a bisulfate : These may be found on a range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines.
Mammalian Sulfatases: Biochemistry, Disease Manifestation, and …
WEBJul 24, 2022 · Sulfatases are enzymes that catalyze the removal of sulfate from biological substances, an essential process for the homeostasis of the body. They are commonly activated by the unusual amino acid formylglycine, which is formed from cysteine at the catalytic center, mediated by a formylglycine-generating enzyme as a post-translational …
SulfAtlas, the sulfatase database: state of the art and new ...
WEBNov 1, 2022 · Abstract. SulfAtlas ( https://sulfatlas.sb-roscoff.fr/) is a knowledge-based resource dedicated to a sequence-based classification of sulfatases. Currently four sulfatase families exist (S1–S4) and the largest family (S1, formylglycine-dependent sulfatases) is divided into subfamilies by a phylogenetic approach, each subfamily …
Angewandte Chemie International Edition - Wiley Online Library
WEBNov 2, 2004 · Sulfatases, which cleave sulfate esters in biological systems, play a key role in regulating the sulfation states that determine the function of many physiological molecules. Sulfatase substrates range from small cytosolic steroids, such as estrogen sulfate, to complex cell-surface carbohydrates, such as the glycosaminoglycans.
Sulfatase - an overview | ScienceDirect Topics
WEBThree sulfatases (Table I .) can act on unsaturated sulfated disaccharides from chondroitin sulfate but, at present, only glycuronide-2-sulfatase (2-Sase) is available for the identification from heparan sulfate or heparin ( Table II ). Table 2. Specificities of Sulfatases on Unsaturated Disaccharides.
SULFATASES AND HUMAN DISEASE | Annual Reviews
WEBSulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases.
Sulfatase - an overview | ScienceDirect Topics
WEBMultiple Sulfatase Deficiency. Multiple sulfatase deficiency is an autosomal recessive disorder that leads to accumulation and excretion of sulfatides, sulfated glycosaminoglycans, sphingolipids, and steroid sulfates. The enzymatic defect affects sulfatase enzymes.
The sulfatase gene family - ScienceDirect
WEBJun 1, 1997 · During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a …
Human sulfatases: a structural perspective to catalysis
WEBThe sulfatase family of enzymes catalyzes hydrolysis of sulfate ester bonds of a wide variety of substrates. Seventeen genes have been identified in this class of sulfatases, many of which are associated with genetic disorders leading to reduction or loss of function of the corresponding enzymes.
Sulfatases and human disease - PubMed
WEBSulfatases are a highly conserved family of proteins that cleave sulfate esters from a wide range of substrates. The importance of sulfatases in human metabolism is underscored by the presence of at least eight human monogenic diseases caused by the deficiency of individual sulfatases.
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