Survivin - Wikipedia
WebSurvivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell ...
Survivin at a glance - PMC - National Center for Biotechnology …
WebApr 1, 2019 · Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.
Survivin: A molecular biomarker in cancer - PubMed
WebSurvivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin has consistently been identified by molecular profiling analysis to be associated with high ….
Survivin: a unique target for tumor therapy - PMC
WebJun 23, 2016 · Survivin expression confers a survival advantage on tumour cells and can be a universal therapeutic and diagnostic target for all tumours. Survivin protein has been shown to induce CTL response in vitro when processed and presented by dendritic cells and Survivin derived peptides prime CTLs in vivo in murine model of melanoma .
Survivin at a glance | Journal of Cell Science - The Company of …
WebApr 4, 2019 · Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target.
Survivin at a glance - PubMed
WebApr 4, 2019 · Abstract. Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential ...
Survivin, cancer networks and pathway-directed drug discovery
WebNature Reviews Cancer - In the past 10 years, much has been learned about the biology of the inhibitor of apoptosis protein survivin and its expression and roles in cancer. Does survivin...
Validating survivin as a cancer therapeutic target - Nature
WebSurvivin is a unique member of the IAP family. It is associated with several subcellular compartments and its expression is regulated by many signalling pathways. The survivin pathway...
Survivin, a key player in cancer progression, increases in ... - Nature
WebMay 18, 2017 · Abstract. Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for ...
Cancer therapeutics using survivin BIRC5 as a target: what can we …
WebAug 22, 2019 · Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field.
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