Translocation: Types, Causes, and Related Conditions - Verywell …
WEBJun 28, 2023 · Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes. When translocation occurs, it causes flaws in chromosomes, which can lead to serious genetic and health conditions like cancer.
Chromosomal translocation - Wikipedia
WEBIn genetics, chromosome translocation is a phenomenon that results in unusual rearrangement of chromosomes. This includes balanced and unbalanced translocation, with two main types: reciprocal , and Robertsonian translocation.
Translocation - National Human Genome Research Institute
WEB4 days ago · A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of chromosomal translocations can be important for the diagnosis of certain genetic diseases and disorders.
What Are Translocations? What Disorders Do They Cause? - WebMD
WEBJul 21, 2022 · Translocations are important when they occur in a large population of cells. Translocation mutations are most harmful when they occur in a sperm, ovum, or zygote. At that time, there is only...
The biogenesis of chromosome translocations - PMC - National …
WEBBeyond their role as disease agents, translocations are used as decisive diagnostic indicators, as they are easily and accurately detected using cytogenetic methods. Despite their prevalence and functional importance, our understanding of their genesis is still remarkably rudimentary. Figure 1.
Mechanisms driving chromosomal translocations: lost in time …
WEBJun 8, 2021 · Translocations arise when an end of one chromosome break is mistakenly joined to an end from a different chromosome break. Since translocations can lead to developmental disease and cancer, it...
The biogenesis of chromosome translocations | Nature Cell …
WEBApr 1, 2014 · Roukos and Misteli discuss the spatial aspect of chromosome translocation and the role of DNA repair pathways in this process. Chromosome translocations are catastrophic genomic events and often ...
Mechanisms driving chromosomal translocations: lost in time and …
WEBTranslocations are simple “cut and paste” structural genome variants (SVs) that can arise when there are two co-existing breaks on different chromosomes, and the incorrect ends are joined together (i.e. an end from one chromosome is …
Human Chromosome Translocations and Cancer - Nature
WEBTranslocations generate novel chromosomes. In a translocation, a segment from one chromosome is transferred to a nonhomologous chromosome or to a new site on the same chromosome.
Translocation | SpringerLink
WEBSep 7, 2020 · A translocation is a chromosomal ability, in which chromosome part breaks down and reattaches with another chromosome. It is easily quantified by the evaluation of the karyotype of the affected cells. Chromosomal translocation usually observed in the case of leukemia and other cancers.
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