Tumorigenesis: it takes a village | Nature Reviews Cancer
WebJul 2, 2015 · This could also very possibly be true for enhanced tumorigenicity in heterogeneous cancer cell populations 35,36. It is widely known that cancer cells, just like bacteria, are able to secrete ...
Tumorigenicity assessment of cell therapy products: The need …
WebNov 1, 2019 · Tumorigenicity risk has been primarily linked to CTPs derived from hPSCs. Indeed, the undifferentiated cells present intrinsic tumorigenic properties and can form teratomas in immunodeficient animals, which have …
Carcinogenesis - Wikipedia
WebCarcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.
Assessing Tumorigenicity in Stem Cell-Derived Therapeutic …
WebJul 19, 2023 · As healthcare professionals, it is essential to consider and evaluate the potential harm that any treatment may cause. The tumorigenicity inherent in stem cell therapy has received significant attention, and multiple assays have been developed to detect, trace, and eliminate the risk of tumorigenicity associated with stem cell products.
Tumorigenicity assessment of cell therapy products: The need ... - PubMed
WebAbstract. Pluripotent stem cells offer the potential for an unlimited source for cell therapy products. However, there is concern regarding the tumorigenicity of these products in humans, mainly due to the possible unintended contamination of undifferentiated cells or transformed cells.
Tumorigenicity as a Clinical Hurdle for Pluripotent Stem Cell …
WebMore than therapeutic efficacy, risks to patient safety are a primary focus in phase 1 clinical trials that often dictate the opinions of both the scientific community and lay public. In this regard, tumorigenicity is a potential hurdle that could halt ESC and iPSC research.
Tumorigenicity as a clinical hurdle for pluripotent stem cell ... - Nature
WebAug 6, 2013 · Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies. Andrew S Lee, Chad Tang, Mahendra S Rao, Irving L Weissman & Joseph C Wu. Nature Medicine 19 , 998–1004 ( 2013) Cite this...
Role of tumor microenvironment in tumorigenesis - PMC
WebFeb 25, 2017 · Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis.
Interfacial geometry dictates cancer cell tumorigenicity - Nature
WebApr 4, 2016 · Interfacial geometry dictates cancer cell tumorigenicity. Junmin Lee, Amr A. Abdeen, Kathryn L. Wycislo, Timothy M. Fan & Kristopher A. Kilian. Nature Materials 15 , 856–862 ( 2016) Cite this...
Tumorigenicity of pluripotent stem cells: biological insights from ...
WebSep 29, 2010 · Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging | Journal of The Royal Society Interface. Articles. Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging. Nigel G. Kooreman. and. Joseph C. Wu. Published: 29 September 2010 https://doi.org/10.1098/rsif.2010.0353.focus. Abstract.
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