Kalamazoo is a city in the southwest region of the U.S. state of Michigan. It is the county seat of Kalamazoo County. At the 2020 census, Kalama…Kalamazoo is a city in the southwest region of the U.S. state of Michigan. It is the county seat of Kalamazoo County. At the 2020 census, Kalamazoo had a population of 73,598. Kalamazoo is the major city of the Kalamazoo-Portage Metropolitan Statistical Area, which had a population of 261,670 in 2020.
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