Bukhara is the seventh-largest city in Uzbekistan by population, with 280,187 residents as of 1 January 2020. It is the capital of Bukhara R…Bukhara is the seventh-largest city in Uzbekistan by population, with 280,187 residents as of 1 January 2020. It is the capital of Bukhara Region. The mother tongue of the majority of people of Bukhara is the Tajik dialect of the Persian language, although Uzbek is spoken as a second language by most residents.