Middletown is a city located in Butler and Warren counties in the southwestern part of the U.S. state of Ohio. The population as of the …Middletown is a city located in Butler and Warren counties in the southwestern part of the U.S. state of Ohio. The population as of the 2020 census was 50,987. It is part of the Cincinnati metropolitan area, located 29 miles northeast of Cincinnati and 20 miles southwest of Dayton.
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