Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. At the 2020 census, the population was 249,…Winston-Salem is a city in and the county seat of Forsyth County, North Carolina, United States. At the 2020 census, the population was 249,545, making it the fifth-most populous city in North Carolina, and the 90th-most populous city in the United States. The population of the Winston-Salem metropolitan area was estimated to be 695,630 in 2023. It is the second-most populous city in North Carolina's Piedmont Triad region, home to about 1.7 million residents.
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