Other growth-related conditions included in this Phase II trial were Noonan syndrome, Neurofibromatosis type 1, Costello syndrome, NPR2 mutations and Aggrecan mutations. This manuscript includes ...

The ECM is a hydrated composite of a collagen II/IX/XI network that entraps aggrecan. They resist tensile stress and provide load bearing and energy dissipating functions. Besides the major two ...

Lin Han obtained his BE degree from Tsinghua University in Beijing, P. R. China, and his PhD degree from the Massachusetts Institute of Technology in the area of Bio- and Polymeric Materials. After ...

Aggrecan, collagen and molecular biomarkers are the molecules responsible for maintaining cartilage integrity, function and metabolism, and the loss of some of these components, as occur when the OA ...

Erosion results from breakdown of cartilage components, including aggrecan (caused by a disintegrin and metalloproteinase with thrombospondin motifs [ADAMTS] enzymes), the collagen network (caused ...

The study also enrolled patients with other growth-related conditions – including Noonan syndrome, neurofibromatosis type 1, Costello syndrome, NPR2 mutations, and Aggrecan mutations – but ...

Other growth-related conditions included in this phase 2 trial were Noonan syndrome, Neurofibromatosis type 1, Costello syndrome, NPR2 mutations and Aggrecan mutations. This manuscript includes ...

The quick response is possible as larger proteoglycans associated with tendinopathy (aggrecan and versican) and some glycoproteins (hyaluronan) can be upregulated in a timespan varying from minutes to ...