Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

It is unclear whether these beneficial effects are due solely to aldosterone blockade, as MR has a similar affinity for cortisol. We examined the relationships between plasma and urinary steroid ...

RADNOR, Pa., May 06, 2024 (GLOBE NEWSWIRE) -- (NASDAQ: MLYS), a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension, chronic kidney disease (CKD) and other ...

A little benign nodule, occurring in one out of every twenty persons with hypertension, is the cause. The nodule generates aldosterone, a hormone that regulates how much salt is in the body. The ...

Blockade of the renin–angiotensin system has beneficial effects in patients with diabetic nephropathy; however, this treatment can induce aldosterone breakthrough and thus become ineffective.

By Dr. Sanchari Sinha Dutta, Ph.D. In a recent study published in The American Journal of Clinical Nutrition , researchers ...

CTX340 is designed to inhibit production of hepatic angiotensinogen (AGT), a validated target to modulate the renin-angiotensin-aldosterone system (RAAS) and normalize blood pressure durably with a ...

New research is revealing potential impacts on the hormones of sea turtles affected by the Deepwater Horizon oil spill in the Gulf of Mexico.The 2010 ...

It clinical-stage product candidate is lorundrostat, a proprietary, orally administered, highly selective aldosterone synthase inhibitor for the treatment of cardiorenal conditions affected by ...

In that study, just one in five patients with MR secondary to HF received triple therapy with a renin-angiotensin-aldosterone system (RAAS) inhibitor or ARNI, beta-blocker, and MRA before undergoing M ...

A new study suggests a link between taking medication for hypertension, or high blood pressure, and a reduced risk of ...