Tumour cells become aneuploid as a result of aberrant mitotic divisions. These aberrant divisions are caused by divisions with a multipolar spindle as a result of previous defects in cytokinesis ...

These signals enabled the scientists to correctly identify the 12 women who carried aneuploid fetuses and the six whose pregnancies were normal. Their results matched those of amniocentesis or CVS ...

Genetic improvement involving hybridisation across ploidy levels (diploid, aneuploid or polyploid) is important in wide crossing involving polyploid plant species such as rice wild relatives and ...

A subset of tumor cells with an abnormal number of chromosomes (aneuploid) are reliant on KIF18A and show rapid cell killing in vitro and in vivo upon KIF18A inhibitor treatment, while cells with ...

It remains unclear what makes early embryonic cells susceptible to mitotic errors and what is the fate of aneuploid cells during development. Early human embryogenesis is experimentally inaccessible, ...

Robert A. Copeland, Chief Scientific Officer, to provide major symposium presentation on inhibition of key RNA-modifying enzymes as precision cancer therapeutics ...