Expert Rev Anticancer Ther. 2012;12(5):643-654. In a Phase II study of enzastaurin in heavily pretreated patients with recurrent GBM, an objective radiographic response rate of 26% was shown at ...

Thus, by any measure, the expectations for Folkman's antiangiogenic agents were far beyond reason. Endostatin, the second of the antiangiogenic agents discovered by Michael O'Reilly less than half ...

Antiangiogenic drugs, crizotinib, and ICIs were associated with the development of hypogonadism in high-risk men who were treated for cancer. Hypogonadism and its management have an impact on symptom ...

Figure 1: α v β 3 as a mediator of antiangiogenic regulators. Figure 2: Trans-dominant inhibition of proangiogenic integrins. In presenting these models for negative regulation by α v integrins ...

Lignans are a type of phytoestrogen antioxidant compound with antiangiogenic properties, which means they may stop tumors from forming new blood vessels and growing. Flax also contains omega-3 ...

A recent study suggests a modified model incorporating diffusion-weighted MRI can more accurately predict ovarian cancer primary debulking surgery outcomes compared with the standard, widely used ...

Brivanib (BMS-582664) is a novel, orally available and selective R-TKi that targets the angiogenesis receptors VEGFR-2 and FGFR-1 and -2. It has been reported to be an effective anti-tumor agent ...