Consequently, these ADCs would work best in tumors that not only have high levels of target antigen expression but also have high levels of carboxyesterase activity. As with MDX-1203, clinical ...

Decades of evidence shows that exercise leads to healthier, longer lives. Researchers are just starting to work out what it ...

Biotransformation of methylphenidate by the carboxylesterase CES1A1 is rapid and extensive leading to the main, de-esterified metabolite α-phenyl-2-piperidine acetic acid (ritalinic acid), which ...

This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

Circ Cardiovasc Genet. 2013 Apr;6(2):184-92. doi: 10.1161/CIRCGENETICS.111.964627. Epub 2013 Feb 5. The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active ...