Decades of evidence shows that exercise leads to healthier, longer lives. Researchers are just starting to work out what it ...

This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

Biotransformation of methylphenidate by the carboxylesterase CES1A1 is rapid and extensive leading to the main, de-esterified metabolite α-phenyl-2-piperidine acetic acid (ritalinic acid), which ...

CES: Carboxylesterase; IRN: Irinotecan. Tumor vasculature normalization. Extended exposure to SN38 provided by Irinophore C™ induces vascular normalization by a direct cytotoxicity on ...

Circ Cardiovasc Genet. 2013 Apr;6(2):184-92. doi: 10.1161/CIRCGENETICS.111.964627. Epub 2013 Feb 5. The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active ...

The principal biochemical feature of rodents is the presence of carboxylesterase in blood plasma, which is a target for OPs and can greatly distort their specific effects. The present study was ...