as well as for the future development of novel chemotherapeutics. "City of Hope has world leaders in cancer research. They also have the infrastructure to drive translational drug discovery from ...

Given the preclinical and clinical monotherapy toxicity profile of saruparib, the question becomes whether it will safely combine with other therapeutics -- particularly chemotherapeutics ...

Survivors of childhood cancer are at increased risk for cardiovascular disease, for which a risk factor is their greater ...

ChemoRad NP is a biodegradable, biocompatible NP capable of delivering both chemotherapeutics and radiotherapeutics efficiently. Using prostate cancer as a disease model, we demonstrated the ...

The cycle from hot to cold to hot again can take 10-15 years and a new technology may go through more than one such cycle (as ...

In Prof. Karen Holman's research group, students investigate fundamental chemical reactions of ruthenium anti-cancer drugs and carry out biochemical studies related to the mechanisms of action of this ...

An important area of application is nanobiotechnology-based delivery of therapy for brain tumors across the BBB, including NP formulations of chemotherapeutics and gene transfer. NPs enable the ...

Findings suggest regular aspirin use may have an active role in enhancing Immunosurveillance against colorectal cancer.

Reporting in Cancer Cell, MacDiarmid and colleagues now describe a promising new technology that firmly encapsulates chemotherapeutics into bacterial minicells, which are then guided by antibodies ...

Conventional chemotherapeutics disrupt mitotic events in proliferating cells. By exploiting the growth fraction differential between tumor cells and those of normal host tissues, tumor reduction ...

One of my current projects is investigating how TREM2, a protein expressed on the immune cells of the brain, can mediate tumor suppression mechanisms of a platinum-IV chemotherapeutics in colorectal ...

All genetic risks appeared magnified by childhood exposure to alkylating agents, a common class of chemotherapeutics. "We found DNA variants in survivors that increase the risk of type 2 diabetes ...