Almost all people with two copies of a genetic variant called APOE4 show signs of Alzheimer’s disease, according to a new study of people predominantly of European ancestry. The findings suggest that people with two copies of the gene—who are called APOE4 homozygotes—have a distinct genetic form of Alzheimer’s.

People who carry two copies of the APOE4 gene are virtually guaranteed to develop Alzheimer's and face symptoms at an earlier age, researchers reported on Monday in a study that could redefine such carriers as having a new genetic form of the mind-wasting disease.

Researchers have identified a genetic form of late-onset Alzheimer’s disease in people who inherit two copies of the APOE4 gene. The study marks a breakthrough.

Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the Neurology Service at the same hospital,

The research focused on a variant called APOE4 and largely looked at people of European ancestry—risk levels are different for other groups, the authors say

"The data clearly show that having two copies of the APOE4 gene not only increases the risk, but also anticipates the onset of Alzheimer's, reinforcing the need for specific preve

People with two copies of the gene variant APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such patients could be diagnosed years before symptoms.

Study suggests almost everyone with two copies of genetic variant ApoE4 goes on to develop disease