The first pathological descriptions of the disease 150 years ago already showed that demyelinated axons could degenerate. Recent evidence suggests that multiple sclerosis also affects neurons ...

Paroxysmal pain may be related to high-frequency bursts generated in demyelinated Aβ-fibers. Allodynia may be due to a peripheral mechanism, reflecting an abnormal reduction of the mechanical ...

Immunohistochemical analysis also revealed striking gliosis in demyelinated areas. Activated microglia were detected early in the phenotype and prior to axonal loss/demyelination, suggesting that ...

Rieko Muramatsu (NCNP, Japan) addressed how circulating factors—FGF21 and apelin—promote remyelination of demyelinated lesions in the central nervous system by stimulating the proliferation ...