More information: Jing Fang et al, A Single-domain Protein Catenane of Dihydrofolate Reductase, National Science Review (2023 ...

How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the ...

Expert Rev Clin Pharmacol. 2009;2(6):661-672. Several semisynthetic glycopeptide antibiotics for example dalbavancin, telavancin and oritavancin, have been developed to serve as an alternative to ...

The company also develops ADX-629, an orally administered RASP modulator for treatment of COVID-19, atopic asthma, psoriasis, and alcohol intoxication; and ADX-2191, a dihydrofolate reductase ...

Gram-positive cocci Trimethoprim Benzyl-pyrimidine Folate synthesis inhibition (via inhibition of dihydrofolate reductase) Gram-negative bacteria Dapsone Diamino-diphenyl sulfone Folate synthesis ...

The scope and nature of the problem. Although tropical parasites are familiar to most scientists because of their exotic biology, they are in fact the agents of major global health problems.

We characterize the activity of fluorofolin, a potent inhibitor of dihydrofolate reductase, against Pseudomonas aeruginosa. By exploiting a divergence in thymidine metabolism, fluorofolin becomes ...

How mutations impact protein stability and structure dynamics is crucial for understanding the molecular mechanism of the disease and the targeted drug design. However, probing the molecular ...